HLA Association with Drug-Induced Adverse Reactions
المؤلفون المشاركون
Su, Shih-Chi
Wang, Chuang-Wei
Chung, Wen-Hung
Fan, Wen-Lang
Shiao, Meng-Shin
Hui, Rosaline Chung-Yee
Chang, Ya-Ching
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Adverse drug reactions (ADRs) remain a common and major problem in healthcare.
Severe cutaneous adverse drug reactions (SCARs), such as Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening.
A number of recent studies demonstrated that ADRs possess strong genetic predisposition.
ADRs induced by several drugs have been shown to have significant associations with specific alleles of human leukocyte antigen (HLA) genes.
For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B∗57:01).
The incidences of abacavir hypersensitivity are much higher in Caucasians compared to other populations due to various allele frequencies in different ethnic populations.
The antithyroid drug- (ATDs- ) induced agranulocytosis are strongly associated with two alleles: HLA-B∗38:02 and HLA-DRB1∗08:03.
In addition, HLA-B∗15:02 allele was reported to be related to carbamazepine-induced SJS/TEN, and HLA-B∗57:01 in abacavir hypersensitivity and flucloxacillin induced drug-induced liver injury (DILI).
In this review, we summarized the alleles of HLA genes which have been proposed to have association with ADRs caused by different drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Wen-Lang& Shiao, Meng-Shin& Hui, Rosaline Chung-Yee& Su, Shih-Chi& Wang, Chuang-Wei& Chang, Ya-Ching…[et al.]. 2017. HLA Association with Drug-Induced Adverse Reactions. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1181693
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Wen-Lang…[et al.]. HLA Association with Drug-Induced Adverse Reactions. Journal of Immunology Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1181693
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Wen-Lang& Shiao, Meng-Shin& Hui, Rosaline Chung-Yee& Su, Shih-Chi& Wang, Chuang-Wei& Chang, Ya-Ching…[et al.]. HLA Association with Drug-Induced Adverse Reactions. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1181693
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181693
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر