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Improved Analgesic and Anti-Inflammatory Effect of Diclofenac Sodium by Topical Nanoemulgel: Formulation Development—In Vitro and In Vivo Studies
المؤلفون المشاركون
Md, Shadab
Alhakamy, Nabil A.
Akhter, Sohail
Awan, Zuhier A. Y.
Aldawsari, Hibah M.
Kotta, Sabna
Shoaib Alam, Md
Khan, Mohammad A.
Ghamidi, Jawad Ahmad
Sivakumar, Ponnurengam Malliappan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The present study aimed to develop diclofenac sodium nanoemulgel for managing pain and inflammation using the low-energy emulsification technique.
Nanoemulsion of diclofenac was formulated using clove oil with adequate amount of surfactants and cosurfactants, and it was converted to hydrogel form using Carbopol 980 as the gelling agent.
The droplet size of the oil globules in the nanoemulsion was found to be 64.07 ± 2.65 nm with a low polydispersity index (0.238 ± 0.02) along with high negative zeta potential (−39.06 mV).
The developed nanoemulgel exhibited non-Newtonian and pseudoplastic behavior.
The in vitro release profile of the developed nanoemulgel was higher as compared to marketed and conventional gel.
The carrageenan-induced paw edema test was performed in rats to evaluate the anti-inflammatory activity of developed nanoemulgel.
The developed nanoemulgel showed significantly higher (p<0.01) effect in reducing pain and inflammation symptoms as compared to marketed as well as conventional gel of diclofenac.
The overall findings of the study suggest that the developed nanoemulgel formulation of diclofenac can be used as a potential approach for the management of pain and inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Md, Shadab& Alhakamy, Nabil A.& Aldawsari, Hibah M.& Kotta, Sabna& Ghamidi, Jawad Ahmad& Akhter, Sohail…[et al.]. 2020. Improved Analgesic and Anti-Inflammatory Effect of Diclofenac Sodium by Topical Nanoemulgel: Formulation Development—In Vitro and In Vivo Studies. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1181699
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Md, Shadab…[et al.]. Improved Analgesic and Anti-Inflammatory Effect of Diclofenac Sodium by Topical Nanoemulgel: Formulation Development—In Vitro and In Vivo Studies. Journal of Chemistry No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1181699
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Md, Shadab& Alhakamy, Nabil A.& Aldawsari, Hibah M.& Kotta, Sabna& Ghamidi, Jawad Ahmad& Akhter, Sohail…[et al.]. Improved Analgesic and Anti-Inflammatory Effect of Diclofenac Sodium by Topical Nanoemulgel: Formulation Development—In Vitro and In Vivo Studies. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1181699
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181699
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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