Safety of Human Papillomavirus 9-Valent Vaccine: A Meta-Analysis of Randomized Trials

المؤلفون المشاركون

Gonçalves, Ana Katherine
Costa, Ana Paula Ferreira
Cobucci, Ricardo Ney Oliveira
da Silva, Janine Medeiros
da Costa Lima, Paulo Henrique
Giraldo, Paulo César

المصدر

Journal of Immunology Research

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-07-24

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأحياء

الملخص EN

Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years.

In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus.

Studies evaluating its safety are rare.

Thus, we performed a meta-analysis of three clinical trials assessing adverse effects on women randomly vaccinated with HPV9 or tetravalent vaccine (HPV4), with the objective of analyzing whether the HPV9 is as safe as HPV4.

An electronic data search was performed through the PubMed, Embase, Scopus, Web of Science, and SciELO databases.

The studies selected 27,465 women who received one of the two vaccines.

Pain (OR 1.72; 95% CI 1.62–1.82) and erythema (OR 1.29; 95% CI 1.21–1.36) occurred significantly more in the HPV9 group.

However, there was no significant difference between the groups for the following adverse effects: headache (OR 1.07; 95% CI 0.99–1.15), dizziness (OR 1.09; 95% CI 0.93–1.27), and fatigue (OR 1.09; 95% CI 0.91–1.30), and the occurrence of serious events related to vaccination was similarly rare among those vaccinated.

Therefore, our findings demonstrate that HPV9 in female patients is as safe as the tetravalent vaccine.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Costa, Ana Paula Ferreira& Cobucci, Ricardo Ney Oliveira& da Silva, Janine Medeiros& da Costa Lima, Paulo Henrique& Giraldo, Paulo César& Gonçalves, Ana Katherine. 2017. Safety of Human Papillomavirus 9-Valent Vaccine: A Meta-Analysis of Randomized Trials. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1181742

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Costa, Ana Paula Ferreira…[et al.]. Safety of Human Papillomavirus 9-Valent Vaccine: A Meta-Analysis of Randomized Trials. Journal of Immunology Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1181742

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Costa, Ana Paula Ferreira& Cobucci, Ricardo Ney Oliveira& da Silva, Janine Medeiros& da Costa Lima, Paulo Henrique& Giraldo, Paulo César& Gonçalves, Ana Katherine. Safety of Human Papillomavirus 9-Valent Vaccine: A Meta-Analysis of Randomized Trials. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1181742

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1181742