Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils
المؤلفون المشاركون
Ear, Thornin
Tatsiy, Olga
Allard, Frédérick L.
McDonald, Patrick P.
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Neutrophils play a critical role in innate immunity and also influence adaptive immune responses.
This occurs in good part through their production of inflammatory and immunomodulatory cytokines, in conjunction with their prolonged survival at inflamed foci.
While a picture of the signaling machinery underlying these neutrophil responses is now emerging, much remains to be uncovered.
In this study, we report that neutrophils constitutively express various Src family isoforms (STKs), as well as Syk, and that inhibition of these protein tyrosine kinases selectively hinders inflammatory cytokine generation by acting posttranscriptionally.
Accordingly, STK or Syk inhibition decreases the phosphorylation of signaling intermediates (e.g., eIF-4E, S6K, and MNK1) involved in translational control.
By contrast, delayed apoptosis appears to be independent of either STKs or Syk.
Our data therefore significantly extend our understanding of which neutrophil responses are governed by STKs and Syk and pinpoint some signaling intermediates that are likely involved.
In view of the foremost role of neutrophils in several chronic inflammatory conditions, our findings identify potential molecular targets that could be exploited for future therapeutic intervention.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ear, Thornin& Tatsiy, Olga& Allard, Frédérick L.& McDonald, Patrick P.. 2017. Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181790
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ear, Thornin…[et al.]. Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181790
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ear, Thornin& Tatsiy, Olga& Allard, Frédérick L.& McDonald, Patrick P.. Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181790
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181790
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر