T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers
المؤلفون المشاركون
Mietelska-Porowska, Anna
Wojda, Urszula
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-15
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder and the main cause of dementia.
The disease is among the leading medical concerns of the modern world, because only symptomatic therapies are available, and no reliable, easily accessible biomarkers exist for AD detection and monitoring.
Therefore extensive research is conducted to elucidate the mechanisms of AD pathogenesis, which seems to be heterogeneous and multifactorial.
Recently much attention has been given to the neuroinflammation and activation of glial cells in the AD brain.
Reports also highlighted the proinflammatory role of T lymphocytes infiltrating the AD brain.
However, in AD molecular and cellular alterations involving T cells and immune mediators occur not only in the brain, but also in the blood and the cerebrospinal fluid (CSF).
Here we review alterations concerning T lymphocytes and related immune mediators in the AD brain, CSF, and blood and the mechanisms by which peripheral T cells cross the blood brain barrier and the blood-CSF barrier.
This knowledge is relevant for better AD therapies and for identification of novel biomarkers for improved AD diagnostics in the blood and the CSF.
The data will be reviewed with the special emphasis on possibilities for development of AD biomarkers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mietelska-Porowska, Anna& Wojda, Urszula. 2017. T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1181835
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mietelska-Porowska, Anna& Wojda, Urszula. T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers. Journal of Immunology Research No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1181835
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mietelska-Porowska, Anna& Wojda, Urszula. T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1181835
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181835
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر