Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application
المؤلفون المشاركون
Anibal, Fernanda F.
Mercante, Luiza A.
Mattoso, Luiz H. C.
Correa, Daniel S.
Locilento, Danilo A.
Andre, Rafaela S.
Luna, Genoveva L. F.
Brassolatti, Patricia
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The development of nanofibrous membranes with tunable wettability, degradation, and biocompatibility is highly keen for biomedical applications, including drug delivery and wound dressing.
In this study, biocompatible and biodegradable nanofibrous membranes with antioxidant properties were successfully prepared by the electrospinning technique.
The membranes were developed using polylactic acid (PLA) and polyethylene oxide (PEO) as the matrix, with the addition of grape seed extract (GSE), a rich source of natural antioxidants.
The nanofibrous membranes were thoroughly characterized both from the materials and from the biocompatibility point of view.
PLA and PLA/PEO nanofibers showed high encapsulation efficiency, close to 90%, while the encapsulated GSE retained its antioxidant capacity in the membranes.
In vitro release studies showed that GSE diffuses from PLA/GSE and PLA/PEO/GSE membranes in a Fickian diffusion manner, whose experimental data were well fitted using the Korsmeyer-Peppas model.
Furthermore, a higher controlled release of GSE was observed for the PLA/PEO/GSE membrane.
Moreover, culturing experiments with human foreskin fibroblast (HFF1) cells demonstrated that all samples are biocompatible and showed that the GSE-loaded PLA/PEO nanofibrous membranes support better cell attachment and proliferation compared to the PLA/GSE nanofibrous membranes, owing to the superior hydrophilicity.
In summary, the results suggested that the GSE-loaded membranes are a promising topical drug delivery system and have a great potential for wound dressing applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Locilento, Danilo A.& Mercante, Luiza A.& Andre, Rafaela S.& Mattoso, Luiz H. C.& Luna, Genoveva L. F.& Brassolatti, Patricia…[et al.]. 2019. Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1181840
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Locilento, Danilo A.…[et al.]. Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application. Journal of Nanomaterials No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1181840
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Locilento, Danilo A.& Mercante, Luiza A.& Andre, Rafaela S.& Mattoso, Luiz H. C.& Luna, Genoveva L. F.& Brassolatti, Patricia…[et al.]. Biocompatible and Biodegradable Electrospun Nanofibrous Membranes Loaded with Grape Seed Extract for Wound Dressing Application. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1181840
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181840
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر