Difference in Antibody Responses to Mycobacterium tuberculosis Antigens in Japanese Tuberculosis Patients Infected with the BeijingNon-Beijing Genotype
المؤلفون المشاركون
Suzuki, Yasuhiko
Shiratori, Beata
Nakajima, Chie
Chagan-Yasutan, Haorile
Ashino, Yugo
Hattori, Toshio
Zhao, Jingge
Okumura, Masao
Yanai, Hideki
Matsumoto, Makoto
Mizuno, Kazue
Ono, Kenji
Oda, Tetsuya
Matsuba, Takashi
Yoshiyama, Takashi
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The Beijing genotype Mycobacterium tuberculosis (MTB), notorious for its virulence and predisposition to relapse, could be identified by spoligotyping based on genetic heterogeneity.
The plasma samples from 20 cases of Beijing and 16 cases of non-Beijing MTB infected individuals and 24 healthy controls (HCs) were collected, and antibodies against 11 antigens (Rv0679c142Asn, Rv0679c142Lys, Ag85B, Ag85A, ARC, TDM-M, TDM-K, HBHA, MDP-1, LAM, and TBGL) were measured by ELISA.
Compared to the HCs, the MTB infected subjects showed higher titers of anti-Ag85B IgG (positivity 58.2%) and anti-ACR IgG (positivity 48.2%).
Of note, anti-ACR IgG showed higher titer in Beijing MTB infected tuberculosis (TB) patients than in HC (Kruskal–Wallis test, p<0.05), while the levels of anti-Ag85B, anti-TBGL, anti-TDM-K, and anti-TDM-M IgG were higher in non-Beijing TB patients than in HC.
Moreover, anti-Ag85B IgG showed higher response in non-Beijing TB patients than in Beijing TB patients (p<0.05; sensitivity, 76.9% versus 44.4%).
The sensitivity and specificity analysis showed that 78.8% Beijing infected individuals were negative in anti-TBGL-IgG or/and anti-Ag85B-IgG, while 75.0% of those were positive in anti-TBGL-IgA or/and anti-ACR-IgG tests.
These results indicate the possibility of developing antibody-based test to identify Beijing MTB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Jingge& Shiratori, Beata& Okumura, Masao& Yanai, Hideki& Matsumoto, Makoto& Nakajima, Chie…[et al.]. 2017. Difference in Antibody Responses to Mycobacterium tuberculosis Antigens in Japanese Tuberculosis Patients Infected with the BeijingNon-Beijing Genotype. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Jingge…[et al.]. Difference in Antibody Responses to Mycobacterium tuberculosis Antigens in Japanese Tuberculosis Patients Infected with the BeijingNon-Beijing Genotype. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1181860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Jingge& Shiratori, Beata& Okumura, Masao& Yanai, Hideki& Matsumoto, Makoto& Nakajima, Chie…[et al.]. Difference in Antibody Responses to Mycobacterium tuberculosis Antigens in Japanese Tuberculosis Patients Infected with the BeijingNon-Beijing Genotype. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181860
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر