Genetically Modified T-Cell-Based Adoptive Immunotherapy in Hematological Malignancies
المؤلفون المشاركون
Jian, Zhihong
Stary, Creed M.
Xiong, Xiaoxing
Ye, Baixin
Gao, Qingping
Zeng, Zhi
Gu, Lijuan
Wang, Qiongyu
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-02
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
A significant proportion of hematological malignancies remain limited in treatment options.
Immune system modulation serves as a promising therapeutic approach to eliminate malignant cells.
Cytotoxic T lymphocytes (CTLs) play a central role in antitumor immunity; unfortunately, nonspecific approaches for targeted recognition of tumor cells by CTLs to mediate tumor immune evasion in hematological malignancies imply multiple mechanisms, which may or may not be clinically relevant.
Recently, genetically modified T-cell-based adoptive immunotherapy approaches, including chimeric antigen receptor (CAR) T-cell therapy and engineered T-cell receptor (TCR) T-cell therapy, promise to overcome immune evasion by redirecting the specificity of CTLs to tumor cells.
In clinic trials, CAR-T-cell- and TCR-T-cell-based adoptive immunotherapy have produced encouraging clinical outcomes, thereby demonstrating their therapeutic potential in mitigating tumor development.
The purpose of the present review is to (1) provide a detailed overview of the multiple mechanisms for immune evasion related with T-cell-based therapies; (2) provide a current summary of the applications of CAR-T-cell- as well as neoantigen-specific TCR-T-cell-based adoptive immunotherapy and routes taken to overcome immune evasion; and (3) evaluate alternative approaches targeting immune evasion via optimization of CAR-T and TCR-T-cell immunotherapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ye, Baixin& Stary, Creed M.& Gao, Qingping& Wang, Qiongyu& Zeng, Zhi& Jian, Zhihong…[et al.]. 2017. Genetically Modified T-Cell-Based Adoptive Immunotherapy in Hematological Malignancies. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1181913
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ye, Baixin…[et al.]. Genetically Modified T-Cell-Based Adoptive Immunotherapy in Hematological Malignancies. Journal of Immunology Research No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1181913
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ye, Baixin& Stary, Creed M.& Gao, Qingping& Wang, Qiongyu& Zeng, Zhi& Jian, Zhihong…[et al.]. Genetically Modified T-Cell-Based Adoptive Immunotherapy in Hematological Malignancies. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1181913
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181913
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر