Genetic Polymorphisms of Cytotoxic T-Lymphocyte Antigen 4 in Primary Biliary Cholangitis: A Meta-Analysis
المؤلفون المشاركون
Yang, Xing-Chen
Cai, Song-Jie
Li, Shao-Wei
Liu, Chi
Fujino, Masayuki
Li, Xiao-Kang
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background and Aim.
The connection between gene polymorphisms of cytotoxic T-lymphocyte-associated protein 4 (CTLA4) and primary biliary cholangitis (PBC) is still vague and blurred.
The purpose of this study is to precisely estimate the association of the polymorphisms of CTLA4 with the risk of PBC by using a meta-analysis.
Methods.
PubMed and the Chinese National Knowledge Infrastructure (CNKI) database were used to search correlative literatures, and the documents which were about the relationships between the polymorphisms of CTLA4 (rs231775, rs231725, rs3087243, and rs5742909) and PBC were collected as of June 2016.
The strength of correlation based on odds ratios (ORs) and its 95% confidence intervals (95%CIs) was computed by STATA.
Results.
Generally, in rs231775, a significant risk was found in G allele, the value of OR was 1.32, and its 95%CI was 1.19 to 1.47.
The same situation was found in A allele of rs231725, the value of OR was 1.33, and its 95%CI was 1.22 to 1.45.
As genotypic level, different genotypic models were also found to have obvious relevance with PBC in rs231775 and rs231725.
No obvious connections were found in other SNPs.
Conclusion.
This study indicated that the polymorphisms of rs231775 and rs231725 would be the risk factors of PBC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xing-Chen& Fujino, Masayuki& Cai, Song-Jie& Li, Shao-Wei& Liu, Chi& Li, Xiao-Kang. 2017. Genetic Polymorphisms of Cytotoxic T-Lymphocyte Antigen 4 in Primary Biliary Cholangitis: A Meta-Analysis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181925
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xing-Chen…[et al.]. Genetic Polymorphisms of Cytotoxic T-Lymphocyte Antigen 4 in Primary Biliary Cholangitis: A Meta-Analysis. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1181925
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xing-Chen& Fujino, Masayuki& Cai, Song-Jie& Li, Shao-Wei& Liu, Chi& Li, Xiao-Kang. Genetic Polymorphisms of Cytotoxic T-Lymphocyte Antigen 4 in Primary Biliary Cholangitis: A Meta-Analysis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181925
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181925
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر