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Immunization with Bivalent Flagellin Protects Mice against Fatal Pseudomonas aeruginosa Pneumonia
المؤلفون المشاركون
Imani Fooladi, Abbas Ali
Behrouz, Bahador
Hashemi, Farhad B.
Fatemi, Mohammad Javad
Naghavi, Sara
Irajian, Gholamreza
Halabian, Raheleh
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-19
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Pseudomonas aeruginosa lung infections present a major challenge to healthcare systems worldwide because they are commonly associated with high morbidity and mortality.
Here, we demonstrate the protective efficacy of type a and b flagellins (bivalent flagellin) against acute fatal pneumonia in mice.
Mice immunized intranasally with a bivalent flagellin vaccine were challenged by different flagellated strains of P.
aeruginosa in an acute pneumonia model.
Besides the protective effect of the vaccine, we further measured the host innate and cellular immunity responses.
The immunized mice in our study were protected against both strains.
Remarkably, active immunization with type a or b flagellin significantly improved survival of mice against heterologous strain compared to flagellin a or b antisera.
We also showed that after an intranasal challenge by P.
aeruginosa strain, neutrophils are recruited to the airways of vaccinated mice, and that the bivalent flagellin vaccine was proved to be protective by the generated CD4+IL-17+ Th17 cells.
In conclusion, bivalent flagellin vaccine can confer protection against different strains of P.
aeruginosa in an acute pneumonia mouse model by eliciting effective cellular and humoral immune responses, including increased IL-17 production and improved opsonophagocytic killing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Behrouz, Bahador& Hashemi, Farhad B.& Fatemi, Mohammad Javad& Naghavi, Sara& Irajian, Gholamreza& Halabian, Raheleh…[et al.]. 2017. Immunization with Bivalent Flagellin Protects Mice against Fatal Pseudomonas aeruginosa Pneumonia. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1181947
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Behrouz, Bahador…[et al.]. Immunization with Bivalent Flagellin Protects Mice against Fatal Pseudomonas aeruginosa Pneumonia. Journal of Immunology Research No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1181947
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Behrouz, Bahador& Hashemi, Farhad B.& Fatemi, Mohammad Javad& Naghavi, Sara& Irajian, Gholamreza& Halabian, Raheleh…[et al.]. Immunization with Bivalent Flagellin Protects Mice against Fatal Pseudomonas aeruginosa Pneumonia. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1181947
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181947
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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