Synthesis and Characterization of a New Collagen-Alginate Aerogel for Tissue Engineering

الملخص EN

Scaffolds have been used as extracellular matrix analogs to promote cell migration, cell attachment, and cell proliferation.

The use of aerogels and carbon-based nanomaterials has recently been proposed for tissue engineering due to their properties.

The aim of this study is to develop a highly porous collagen-alginate(-graphene oxide) aerogel-based scaffold.

The GO synthesis was performed by Hummers method; a collagen-alginate and collagen-alginate-GO hydrogel were synthetized; then, they were treated by a supercritical drying process.

The aerogels obtained were evaluated by SEM and FTIR.

Osteoblasts were seeded over the scaffolds and evaluated by SEM.

According to the characterization, the aerogels showed a highly porous interconnected network covered by a nonporous external wall.

According to the FTIR, the chemical functional groups of collagen and GO were maintained after the supercritical process.

The SEM images after cell culture showed that a collagen-alginate scaffold promotes cell attachment and proliferation.

The alginate-collagen aerogel-based scaffold could be a platform for tissue engineering since it shows adequate properties.

Further studies are needed to determine the cell interactions with GO.