pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity
المؤلفون المشاركون
Silva, Célio Lopes
Balbino, Bianca
Chiuso-Minicucci, Fernanda
Ishikawa, Larissa Lumi Watanabe
Masson, Ana Paula
Colavite, Priscila Maria
Zorzella-Pezavento, Sofia Fernanda Gonçalves
Ikoma, Maura Rosane Valerio
Marques, Camila
França, Thais Graziela Donegá
Sartori, Alexandrina
da Rosa, Larissa Camargo
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Experimental autoimmune encephalomyelitis (EAE) is a demyelinating pathology of the central nervous system (CNS) used as a model to study multiple sclerosis immunopathology.
EAE has also been extensively employed to evaluate potentially therapeutic schemes.
Considering the presence of an immune response directed to heat shock proteins (hsps) in autoimmune diseases and the immunoregulatory potential of these molecules, we evaluated the effect of a previous immunization with a genetic vaccine containing the mycobacterial hsp65 gene on EAE development.
C57BL/6 mice were immunized with 4 pVAXhsp65 doses and 14 days later were submitted to EAE induction by immunization with myelin oligodendrocyte glycoprotein ( M O G 35 – 55 ) emulsified in Complete Freund’s Adjuvant.
Vaccinated mice presented significant lower clinical scores and lost less body weight.
M O G 35 – 55 immunization also determined less inflammation in lumbar spinal cord but did not change CD4+CD25+Foxp3+ T cells frequency in spleen and CNS.
Infiltrating cells from the CNS stimulated with rhsp65 produced significantly higher levels of IL-10.
These results suggest that the ability of pVAXhsp65 vaccination to control EAE development is associated with IL-10 induction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zorzella-Pezavento, Sofia Fernanda Gonçalves& Chiuso-Minicucci, Fernanda& França, Thais Graziela Donegá& Ishikawa, Larissa Lumi Watanabe& da Rosa, Larissa Camargo& Colavite, Priscila Maria…[et al.]. 2017. pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1181990
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zorzella-Pezavento, Sofia Fernanda Gonçalves…[et al.]. pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity. Journal of Immunology Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1181990
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zorzella-Pezavento, Sofia Fernanda Gonçalves& Chiuso-Minicucci, Fernanda& França, Thais Graziela Donegá& Ishikawa, Larissa Lumi Watanabe& da Rosa, Larissa Camargo& Colavite, Priscila Maria…[et al.]. pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1181990
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181990
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر