Innate Immune Response in Kidney IschemiaReperfusion Injury: Potential Target for Therapy
المؤلفون المشاركون
Thaiss, F.
Kezic, Aleksandra
Stajic, Natasa
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Acute kidney injury caused by ischemia and subsequent reperfusion is associated with a high rate of mortality and morbidity.
Ischemia/reperfusion injury in kidney transplantation causes delayed graft function and is associated with more frequent episodes of acute rejection and progression to chronic allograft nephropathy.
Alloantigen-independent inflammation is an important process, participating in pathogenesis of injurious response, caused by ischemia and reperfusion.
This innate immune response is characterized by the activity of classical cells belonging to the immune system, such as neutrophils, macrophages, dendritic cells, lymphocytes, and also tubular epithelial cells and endothelial cells.
These immune cells not only participate in inflammation after ischemia exerting detrimental influence but also play a protective role in the healing response from ischemia/reperfusion injury.
Delineating of complex mechanisms of their actions could be fruitful in future prevention and treatment of ischemia/reperfusion injury.
Among numerous so far conducted experiments, observed immunomodulatory role of adenosine and adenosine receptor agonists in complex interactions of dendritic cells, natural killer T cells, and T regulatory cells is emphasized as promising in the treatment of kidney ischemia/reperfusion injury.
Potential pharmacological approaches which decrease NF-κB activity and antagonize mechanisms downstream of activated Toll-like receptors are discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kezic, Aleksandra& Stajic, Natasa& Thaiss, F.. 2017. Innate Immune Response in Kidney IschemiaReperfusion Injury: Potential Target for Therapy. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1181995
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kezic, Aleksandra…[et al.]. Innate Immune Response in Kidney IschemiaReperfusion Injury: Potential Target for Therapy. Journal of Immunology Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1181995
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kezic, Aleksandra& Stajic, Natasa& Thaiss, F.. Innate Immune Response in Kidney IschemiaReperfusion Injury: Potential Target for Therapy. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1181995
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181995
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر