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Mechanistic Understanding of the Engineered Nanomaterial-Induced Toxicity on Kidney
المؤلفون المشاركون
Chu, Yanhui
Zhao, Hai-yang
Sun, Bingbing
Li, Luxin
Zhan, Huilu
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
With the rapid development of nanotechnology, engineered nanomaterials (ENMs) have been applied in many fields, such as food industry, biomedicine, and so on.
However, the study on the health and safety implications of ENMs is still insufficient.
Previous studies have shown that nanoparticles under acute or chronic exposure could be transported and accumulated in various organs and tissues, resulting in adverse effects or systemic toxicity.
Among these, the kidney is one of the main organs that exposed ENMs will target through different routes.
One of the important functions of the kidney is to discharge metabolic wastes and exogenous substances from the blood circulation of the whole body.
During ENM exposure, the kidney may become vulnerable to toxicity.
Studies have suggested that nanoparticles exposed to the kidney could provoke glomerular swelling, basilar membrane thickening, degeneration, and necrosis of renal tubular cells.
These adverse effects of nanoparticles on the kidney may be related to their induced oxidative stress, inflammation, autophagy, DNA damage, and ER stress.
This review aims to examine current studies on ENM-induced nephrotoxicity, with the focus on elucidating the potential molecular mechanisms of nanoparticle-induced toxicity on the kidney, which will further facilitate the safer design of ENMs and their applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Hai-yang& Li, Luxin& Zhan, Huilu& Chu, Yanhui& Sun, Bingbing. 2019. Mechanistic Understanding of the Engineered Nanomaterial-Induced Toxicity on Kidney. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1182006
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Hai-yang…[et al.]. Mechanistic Understanding of the Engineered Nanomaterial-Induced Toxicity on Kidney. Journal of Nanomaterials No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1182006
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Hai-yang& Li, Luxin& Zhan, Huilu& Chu, Yanhui& Sun, Bingbing. Mechanistic Understanding of the Engineered Nanomaterial-Induced Toxicity on Kidney. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1182006
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182006
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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