Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity
المؤلفون المشاركون
Zhang, Yun
Jin, Boquan
Ma, Ying
Zhuang, Ran
Zhang, Yusi
Tang, Kang
Zhang, Chunmei
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Haemorrhagic fever with renal syndrome (HFRS) is characterised by an uncontrolled immune response that causes vascular leakage.
Adiponectin (APN) is an adipocytokine involved in prorevascularisation and immunomodulation.
To investigate the possible effects of APN in the pathogenesis of HFRS, total and high molecular weight (HMW) APN levels in the plasma of patients with HFRS were quantified using enzyme-linked immunosorbent assay (ELISA).
Compared with those in healthy controls, the plasma total and HMW APN levels in patients were elevated to different degrees from the fever onset and remained high at the convalescent phase.
Consistent with these results, western blot analysis additionally showed that low molecular weight (LMW), middle molecular weight (MMW), and HMW APN levels were all elevated and contributed to the elevation of the total APN level.
Importantly, sustained high levels of total and HMW APN at the convalescent phase were significantly higher in patients with critical disease than those in patients with mild or moderate disease.
Moreover, total and HMW APN levels negatively correlated with white blood cell count and positively correlated with platelet count and serum albumin level.
These results may provide insights into understanding the roles of total and HMW APN in the pathogenesis of HFRS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Kang& Zhang, Chunmei& Zhang, Yusi& Zhang, Yun& Zhuang, Ran& Jin, Boquan…[et al.]. 2017. Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182009
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Kang…[et al.]. Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1182009
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Kang& Zhang, Chunmei& Zhang, Yusi& Zhang, Yun& Zhuang, Ran& Jin, Boquan…[et al.]. Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182009
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182009
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر