Synthesis, Biological Activity, and Molecular Modeling Studies of Pyrazole and Triazole Derivatives as Selective COX-2 Inhibitors
المؤلفون المشاركون
Hawash, Mohammed
Abualhasan, Murad N.
Assali, Mohyeddin
Sawaftah, Hadeel
Mousa, Ahmed
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-24
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Series of diaryl-based pyrazole and triazole derivatives were designed and synthesized in a facile synthetic approach in order to produce selective COX-2 inhibitor.
These series of derivatives were synthesized by different reactions like Vilsmeier–Haack reaction and click reaction.
In vitro COX-1 and COX-2 inhibition studies showed that five compounds were potent and selective inhibitors of the COX-2 isozyme with IC50 values in 0.551–0.002 μM range.
In the diarylpyrazole derivatives, compound 4b showed the best inhibitory activity against COX-2 with IC50 = 0.017 μM as one of the N-aromatic rings was substituted with sulfonamide and the other aromatic ring was unsubstituted.
However, when the N-aromatic ring was substituted with sulfonamide and the other aromatic ring was substituted with sulfone (compound 4d), best COX-2 selectivity was achieved (IC50 = 0.098 μM, SI = 54.847).
In the diaryltriazole derivatives, compound 15a showed the best inhibitory activity in comparison to all synthesized compounds including the reference celecoxib with IC50 = 0.002 μM and SI = 162.5 as it could better fit the extra hydrophobic pocket which is present in the COX-2 enzyme.
Moreover, the docking study supports the obtained SAR data and binding similarities and differences on both isozymes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Assali, Mohyeddin& Abualhasan, Murad N.& Sawaftah, Hadeel& Hawash, Mohammed& Mousa, Ahmed. 2020. Synthesis, Biological Activity, and Molecular Modeling Studies of Pyrazole and Triazole Derivatives as Selective COX-2 Inhibitors. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1182028
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Assali, Mohyeddin…[et al.]. Synthesis, Biological Activity, and Molecular Modeling Studies of Pyrazole and Triazole Derivatives as Selective COX-2 Inhibitors. Journal of Chemistry No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1182028
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Assali, Mohyeddin& Abualhasan, Murad N.& Sawaftah, Hadeel& Hawash, Mohammed& Mousa, Ahmed. Synthesis, Biological Activity, and Molecular Modeling Studies of Pyrazole and Triazole Derivatives as Selective COX-2 Inhibitors. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1182028
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182028
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر