Glycomacropeptide Attenuates Inflammation, Pruritus, and Th2 Response Associated with Atopic Dermatitis Induced by 2,4-Dinitrochlorobenzene in Rat
المؤلفون المشاركون
Ventura-Juárez, Javier
Muñoz, Fabiola Carolina
Cervantes, Maritza Montserrat
Cervantes-García, Daniel
Jiménez, Mariela
Salinas, Eva
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Atopic dermatitis (AD) is one of the most common skin diseases, whose incidence is increasing in industrialized countries.
The epicutaneous application of a hapten, such as 2,4-dinitrochlorobenzene (DNCB), evokes an experimental murine AD-like reaction.
Glycomacropeptide (GMP) is a dairy bioactive peptide derived from hydrolysis of κ-casein by chymosin action.
It has anti-inflammatory, prebiotic, and immunomodulatory effects.
The present study was aimed to investigate the effect of GMP administration on DNCB-induced AD in rats.
The severity of inflammatory process, pruritus, production of cytokines, and total immunoglobulin E (IgE) content were measured, and the histopathological features were analyzed.
GMP reduced the intensity of inflammatory process and edema of DNCB-induced dermatitis, with a significant decrease in eosinophils recruitment and mast cells hyperplasia.
In addition GMP suppressed the serum levels of total IgE and IL-4, IL-5, and IL-13 expression in AD-lesions.
Besides, the levels of IL-10 were significantly increased.
Remarkably, GMP administration before AD-induction abolished pruritus in dermatitis-like reactions in the rats.
Taken together, these results indicate that GMP has an inhibitory effect on AD by downregulating Th2 dominant immune response, suggesting GMP as a potential effective alternative therapy for the prevention and management of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muñoz, Fabiola Carolina& Cervantes, Maritza Montserrat& Cervantes-García, Daniel& Jiménez, Mariela& Ventura-Juárez, Javier& Salinas, Eva. 2017. Glycomacropeptide Attenuates Inflammation, Pruritus, and Th2 Response Associated with Atopic Dermatitis Induced by 2,4-Dinitrochlorobenzene in Rat. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1182040
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muñoz, Fabiola Carolina…[et al.]. Glycomacropeptide Attenuates Inflammation, Pruritus, and Th2 Response Associated with Atopic Dermatitis Induced by 2,4-Dinitrochlorobenzene in Rat. Journal of Immunology Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1182040
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muñoz, Fabiola Carolina& Cervantes, Maritza Montserrat& Cervantes-García, Daniel& Jiménez, Mariela& Ventura-Juárez, Javier& Salinas, Eva. Glycomacropeptide Attenuates Inflammation, Pruritus, and Th2 Response Associated with Atopic Dermatitis Induced by 2,4-Dinitrochlorobenzene in Rat. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1182040
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182040
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر