Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge
المؤلفون المشاركون
Raeven, René H. M.
van Riet, Elly
Kersten, Gideon F. A.
Metz, Bernard
Pennings, Jeroen L. A.
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Respiratory infection with Bordetella pertussis leads to severe effects in the lungs.
The resulting immunity and also immunization with pertussis vaccines protect against disease, but the induced type of immunity and longevity of the response are distinct.
In this study the effects of priming, by either vaccination or infection, on a subsequent pathogen encounter were studied.
To that end, three postchallenge transcriptome datasets of previously primed mice were combined and compared to the responses in unprimed control mice.
In total, 205 genes showed different transcription activity.
A coexpression network analysis assembled these genes into 27 clusters, combined into six groups with overlapping biological function.
Local pulmonary immunity was only present in mice with infection-induced immunity.
Complement-mediated responses were more prominent in mice immunized with an outer membrane vesicle pertussis vaccine than in mice that received a whole-cell pertussis vaccine.
Additionally, 46 genes encoding for secreted proteins may serve as markers in blood for the degree of protection (Cxcl9, Gp2, and Pla2g2d), intensity of infection (Retnla, Saa3, Il6, and Il1b), or adaptive recall responses (Ighg, C1qb).
The molecular signatures elucidated in this study contribute to better understanding of functional interactions in challenge-induced responses in relation to pertussis immunity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Raeven, René H. M.& Pennings, Jeroen L. A.& van Riet, Elly& Kersten, Gideon F. A.& Metz, Bernard. 2017. Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182153
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Raeven, René H. M.…[et al.]. Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1182153
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Raeven, René H. M.& Pennings, Jeroen L. A.& van Riet, Elly& Kersten, Gideon F. A.& Metz, Bernard. Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182153
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182153
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر