PEGylation of Ginsenoside Rg3-Entrapped Bovine Serum Albumin Nanoparticles: Preparation, Characterization, and In Vitro Biological Studies
المؤلفون المشاركون
Mi, Yu
Zhang, Lijun
Ma, Pei
Zhu, Chenhui
Chi, Lei
Dong, Yanan
Hui, Junfeng
Fan, Daidi
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Ginsenoside Rg3 (Rg3) is one of three triterpene saponins from red ginseng.
It has important structural functions and pharmacological properties.
However, due to its poor solubility, low bioavailability, and short half-life in blood circulation, its clinical application was unsuccessful for the treatment of a variety of cancers.
In order to overcome this limitation, this study prepared mPEGylation-Rg3 bovine serum albumin nanoparticles (mPEG-Rg3-BSA NPs).
The characteristics of the NPs, such as drug entrapment efficiency, drug loading efficiency, surface morphology, thermal stability, and cytotoxicity in vitro, were investigated.
The results showed that the appropriate particle size of the obtained NPs was 149.5 nm, the water solubility and stability were better than free Rg3, and the drug entrapment efficiency and drug loading efficiency were 76.56% and 17.65%, respectively.
Moreover, the cytotoxicity assays of the mPEG-Rg3-BSA NPs and free Rg3 revealed that the mPEG-Rg3-BSA NPs have greater anticancer effects in HepG2 cells and A549 cells.
However, the cytotoxic effect of free Rg3 was higher than the mPEG-Rg3-BSA NPs in L929 cells.
The results indicated that using the mPEGylation method and selecting BSA as a carrier to form the nanodrug carrier system were effective for improving the properties of Rg3.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Lijun& Hui, Junfeng& Ma, Pei& Mi, Yu& Fan, Daidi& Zhu, Chenhui…[et al.]. 2019. PEGylation of Ginsenoside Rg3-Entrapped Bovine Serum Albumin Nanoparticles: Preparation, Characterization, and In Vitro Biological Studies. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1182154
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Lijun…[et al.]. PEGylation of Ginsenoside Rg3-Entrapped Bovine Serum Albumin Nanoparticles: Preparation, Characterization, and In Vitro Biological Studies. Journal of Nanomaterials No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1182154
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Lijun& Hui, Junfeng& Ma, Pei& Mi, Yu& Fan, Daidi& Zhu, Chenhui…[et al.]. PEGylation of Ginsenoside Rg3-Entrapped Bovine Serum Albumin Nanoparticles: Preparation, Characterization, and In Vitro Biological Studies. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1182154
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182154
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر