The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
المؤلفون المشاركون
Simpson, Jodie L.
Xiong, Lingxin
Wang, Fang
Zhang, Chao
Sai, Jingying
Zheng, Jingtong
Wang, Guoqiang
Lu, Junying
Zhang, Weijie
Shi, Yue
Li, Ying
Gibson, Peter G.
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Viral infection is a common trigger for acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
The aim of this study is to investigate the expression of cytokines in AECOPD.
Patients with AECOPD requiring hospitalization were recruited.
Meanwhile healthy volunteers of similar age that accepted routine check-ups and showed no clinical symptoms of inflammatory diseases were also recruited.
Induced sputum and serum were collected.
Induced sputum of participants was processed and tested for thirteen viruses and bacteria.
Forty cytokines were assayed in serum using the Quantibody Human Inflammation Array 3 (Ray Biotech, Inc.).
The most common virus detected in virus positive AECOPD (VP) was influenza A (16%).
No virus was found in controls.
Circulating levels of IL-6, TNF-α, and MCP-1 were elevated in VP and coinfection subjects (p<0.05), while the levels of 37 other cytokines showed no difference, compared with virus negative groups and controls (p>0.05).
Additionally, VP patients were less likely to have received influenza vaccination.
VP patients had a systemic inflammation response involving IL-6, TNF-α, and MCP-1 which may be due to virus-induced activation of macrophages.
There are important opportunities for further investigating AECOPD mechanisms and for the development of better strategies in the management and prevention of virus-related AECOPD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Jingtong& Shi, Yue& Xiong, Lingxin& Zhang, Weijie& Li, Ying& Gibson, Peter G.…[et al.]. 2017. The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182157
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Jingtong…[et al.]. The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1182157
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Jingtong& Shi, Yue& Xiong, Lingxin& Zhang, Weijie& Li, Ying& Gibson, Peter G.…[et al.]. The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1182157
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182157
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر