Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis
المؤلفون المشاركون
Khaiboullina, Svetlana F.
Lombardi, Vincent C.
Anokhin, Vladimir V.
Rizvanov, Albert A.
Khaertynov, Kh. S.
Boichuk, S. V.
Andreeva, A. A.
Satrutdinov, M. A.
Agafonova, E. A.
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Neonatal sepsis is a significant health issue associated with high mortality.
Immune responses associated with neonatal sepsis, such as proinflammatory cytokine production, are believed to play a central role in the pathogenesis of this disease.
In the present study, serum levels of the proinflammatory cytokines TNF-α, IL1-β, and IL-6 and the anti-inflammatory cytokines IL-4 and IL-10 were evaluated for 25 subjects with neonatal sepsis.
We observed that subjects with late onset of sepsis (LOS), as well as those with early onset of sepsis (EOS), had a substantial increase in serum TNF-α.
In contrast to EOS, subjects with LOS demonstrated a significant increase in serum levels IL-6 and IL-10.
Additionally, we observed a significant difference in cytokine profiles between acute and postacute cases of neonatal sepsis.
For instance, the level of proinflammatory cytokines, such as TNF-α and IL-6, was elevated in the acute phase, whereas the production of anti-inflammatory cytokines, such as IL-10, became substantially upregulated during the postacute phase.
Additionally, no correlation was observed between cytokine levels and CRP levels or lymphocyte counts.
Thus, in contrast to CRP levels and lymphocyte counts, examination of the cytokine profile can provide valuable information when determining the most effective therapy for treating neonatal sepsis.
This information may be useful to physicians when determining if anti-inflammatory or immune stimulatory therapy is warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khaertynov, Kh. S.& Boichuk, S. V.& Khaiboullina, Svetlana F.& Anokhin, Vladimir V.& Andreeva, A. A.& Lombardi, Vincent C.…[et al.]. 2017. Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1182162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khaertynov, Kh. S.…[et al.]. Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1182162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khaertynov, Kh. S.& Boichuk, S. V.& Khaiboullina, Svetlana F.& Anokhin, Vladimir V.& Andreeva, A. A.& Lombardi, Vincent C.…[et al.]. Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1182162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر