Phytochemical Screening and Cytotoxic Properties of Ethanolic Extract of Young and Mature Khat Leaves
المؤلفون المشاركون
Alsanosy, Rashad Mohammed
Khardali, Ibrahim Abdu
Khalid, Asaad
Abdalla, Ashraf N.
Sultana, Shahnaz
Al Bratty, Mohammed
Alhazmi, Hassan A.
Ibrahim, Yassin
Banji, David
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The khat plant has been culturally used in many parts of Africa and the Arabian Peninsula for many years to induce psycho-stimulating effect.
Because of the global wide-spreading nature, khat chewing is being considered as a universally growing problem.
Catha abbottii, Catha edulis, and Catha transvaalensis are the three species of khat commonly chewed in Saudi Arabia and nearby regions.
Khat users usually prefer to chew young leaves over mature ones due to the diverse effects produced by both.
Though many of the constituents of khat leaves have been identified, the complete phytochemical profile of young and mature leaves was not performed or compared; also, no evidence is available to affirm the cytotoxicity of young or mature leaves.
Therefore, this study aimed to investigate the phytochemical basis of the differential response of the young and mature leaves and to assess the cytotoxicity of young and mature khat leaves.
Ethanolic extracts of young and mature leaves of three khat cultivars were subjected to GC-MS.
Hierarchical cluster analysis revealed the existence of two major clusters.
The extracts of young leaves were found to contain the maximum content of cathinone; however, methoxyamphetamine was found in only one extract of young leaves.
Cytotoxicity investigations were also conducted on both types of leaves using three cancer cell lines, human breast adenocarcinoma, human ovary adenocarcinoma, and human colon adenocarcinoma and also normal human fetal lung fibroblast cell line was used.
All extracts showed comparable cytotoxicity, IC50 ranging from 22–59 μg/mL on the cancer cells; however, we observed more cytotoxicity against normal cells (IC50: 6–41 μg/mL).
The predominant cytotoxicity on normal cells may pose many health hazards to khat consumers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alsanosy, Rashad Mohammed& Alhazmi, Hassan A.& Sultana, Shahnaz& Abdalla, Ashraf N.& Ibrahim, Yassin& Al Bratty, Mohammed…[et al.]. 2020. Phytochemical Screening and Cytotoxic Properties of Ethanolic Extract of Young and Mature Khat Leaves. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1182228
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alsanosy, Rashad Mohammed…[et al.]. Phytochemical Screening and Cytotoxic Properties of Ethanolic Extract of Young and Mature Khat Leaves. Journal of Chemistry No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1182228
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alsanosy, Rashad Mohammed& Alhazmi, Hassan A.& Sultana, Shahnaz& Abdalla, Ashraf N.& Ibrahim, Yassin& Al Bratty, Mohammed…[et al.]. Phytochemical Screening and Cytotoxic Properties of Ethanolic Extract of Young and Mature Khat Leaves. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1182228
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182228
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر