Adrenomedullin Regulates IL-1β Gene Expression in F480+ Macrophages during Synovial Inflammation
المؤلفون المشاركون
Uchida, Kentaro
Aikawa, Jun
Takano, Shotaro
Miyagi, Masayuki
Takaso, Masashi
Iwabuchi, Kazuya
Inoue, Gen
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Adrenomedullin (AM) plays an important role in the regulation of inflammatory processes; however, the role and expression of AM in synovial inflammation have not been determined.
To investigate the expression and role of AM in inflamed synovial tissue (ST), the gene expression profiles of AM in the ST, including synovial macrophages and fibroblasts, of a murine patellar surgical dislocation model were characterized.
In addition, the effects of interleukin- (IL-) 1β and AM in cultured synovial cells were also examined.
CD11c+ macrophages were found to be elevated in ST of the surgically dislocated patella.
Higher gene expression of CD11c, IL-1β, AM, receptor activity-modifying proteins 2 (RAMP2), and 3 (RAMP3) was also observed in ST obtained from the dislocated side.
AM expression was also significantly increased in synovial fibroblasts and macrophages in response to IL-1β treatment.
Synovial macrophages also highly expressed RAMP3 compared to fibroblasts and this expression was further stimulated by exogenously added IL-1β.
Further, the treatment of the F4/80-positive cell fraction obtained from ST with AM inhibited IL-1β expression.
Taken together, these findings demonstrated that AM was produced by synovial fibroblasts and macrophages in inflamed ST and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takano, Shotaro& Uchida, Kentaro& Miyagi, Masayuki& Inoue, Gen& Aikawa, Jun& Iwabuchi, Kazuya…[et al.]. 2017. Adrenomedullin Regulates IL-1β Gene Expression in F480+ Macrophages during Synovial Inflammation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182284
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takano, Shotaro…[et al.]. Adrenomedullin Regulates IL-1β Gene Expression in F480+ Macrophages during Synovial Inflammation. Journal of Immunology Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1182284
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takano, Shotaro& Uchida, Kentaro& Miyagi, Masayuki& Inoue, Gen& Aikawa, Jun& Iwabuchi, Kazuya…[et al.]. Adrenomedullin Regulates IL-1β Gene Expression in F480+ Macrophages during Synovial Inflammation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182284
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182284
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر