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Adrenomedullin Regulates IL-1β Gene Expression in F480+ Macrophages during Synovial Inflammation
Joint Authors
Uchida, Kentaro
Aikawa, Jun
Takano, Shotaro
Miyagi, Masayuki
Takaso, Masashi
Iwabuchi, Kazuya
Inoue, Gen
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Adrenomedullin (AM) plays an important role in the regulation of inflammatory processes; however, the role and expression of AM in synovial inflammation have not been determined.
To investigate the expression and role of AM in inflamed synovial tissue (ST), the gene expression profiles of AM in the ST, including synovial macrophages and fibroblasts, of a murine patellar surgical dislocation model were characterized.
In addition, the effects of interleukin- (IL-) 1β and AM in cultured synovial cells were also examined.
CD11c+ macrophages were found to be elevated in ST of the surgically dislocated patella.
Higher gene expression of CD11c, IL-1β, AM, receptor activity-modifying proteins 2 (RAMP2), and 3 (RAMP3) was also observed in ST obtained from the dislocated side.
AM expression was also significantly increased in synovial fibroblasts and macrophages in response to IL-1β treatment.
Synovial macrophages also highly expressed RAMP3 compared to fibroblasts and this expression was further stimulated by exogenously added IL-1β.
Further, the treatment of the F4/80-positive cell fraction obtained from ST with AM inhibited IL-1β expression.
Taken together, these findings demonstrated that AM was produced by synovial fibroblasts and macrophages in inflamed ST and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages.
American Psychological Association (APA)
Takano, Shotaro& Uchida, Kentaro& Miyagi, Masayuki& Inoue, Gen& Aikawa, Jun& Iwabuchi, Kazuya…[et al.]. 2017. Adrenomedullin Regulates IL-1β Gene Expression in F480+ Macrophages during Synovial Inflammation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182284
Modern Language Association (MLA)
Takano, Shotaro…[et al.]. Adrenomedullin Regulates IL-1β Gene Expression in F480+ Macrophages during Synovial Inflammation. Journal of Immunology Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1182284
American Medical Association (AMA)
Takano, Shotaro& Uchida, Kentaro& Miyagi, Masayuki& Inoue, Gen& Aikawa, Jun& Iwabuchi, Kazuya…[et al.]. Adrenomedullin Regulates IL-1β Gene Expression in F480+ Macrophages during Synovial Inflammation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1182284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1182284