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Design and Characterization of Endostatin-Loaded Nanoparticles for In Vitro Antiangiogenesis in Squamous Cell Carcinoma
المؤلفون المشاركون
du Toit, Lisa C.
Pillay, Viness
Adeyemi, Samson A.
Choonara, Yahya E.
Kumar, Pradeep
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-04
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
The aim of this study is to effectively enhance antitumor activities of endostatin by preparing polymeric nanocarriers.
NMR and FT-IR spectra confirmed the successful grafting of the CHT-g-PEI and CHT-g-PEI-PEG-NH2 conjugates.
SEM micrographs confirmed the shape of endostatin-loaded nanoparticles to be spherical while both TEM and zeta size results showed nanoparticle’s average size to be 100.6 nm having a positively charged surface with zeta potential of 7.95 mV.
The concentrations of CHT and TPP as well as the changing pH conditions account for the increased swelling pattern of endostatin-loaded nanoparticles and influenced endostatin release in vitro.
PEI increased the overall amine protonation while PEG aggravated endostatin encapsulation and release.
Nanoparticles swell and release endostatin at acidic tumor pH of 6.8 compared to physiological pH of 7.4.
The native CHT-g-PEI-PEG-NH2 conjugate showed high cytocompatibility above 80% cell viability across tested formulations.
Endostatin-loaded nanoparticles showed a significant reduction in cell viability across tested formulations, with 5.32% cell death at 125 μg/mL and 13.36% at 250 μg/mL following 24 hours’ incubation period.
Interestingly, more than a fourfold (61.68%) increment in cytotoxicity was observed at nanoparticle concentration of 1000 μg/mL.
It was concluded that CHT-g-PEI-PEG-NH2 is an effective cargo for endostatin delivery with antiangiogenic effect in squamous cell carcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adeyemi, Samson A.& Choonara, Yahya E.& Kumar, Pradeep& du Toit, Lisa C.& Pillay, Viness. 2017. Design and Characterization of Endostatin-Loaded Nanoparticles for In Vitro Antiangiogenesis in Squamous Cell Carcinoma. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1182813
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adeyemi, Samson A.…[et al.]. Design and Characterization of Endostatin-Loaded Nanoparticles for In Vitro Antiangiogenesis in Squamous Cell Carcinoma. Journal of Nanomaterials No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1182813
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adeyemi, Samson A.& Choonara, Yahya E.& Kumar, Pradeep& du Toit, Lisa C.& Pillay, Viness. Design and Characterization of Endostatin-Loaded Nanoparticles for In Vitro Antiangiogenesis in Squamous Cell Carcinoma. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1182813
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182813
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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