The Dose-Response Relationship between Alcohol Consumption and the Risk of Type 2 Diabetes among Asian Men: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

الملخص EN

The objective of this review was to provide a summary of the literature on the dose-response relationship between alcohol consumption and risk of type 2 diabetes (T2D) in Asian populations, particularly men.

The present study was recorded in PROSPERO as CRD 42019121073.

We searched the PubMed-Medline, Web of Science, and Cochrane Library for studies published in any language since the database inception to January 2019.

Prospective cohort studies were included in the meta-analysis.

Relative risks (RRs) and 95% confidence intervals (CIs) were calculated for random-effects models and dose-response meta-analyses.

In total, 8 prospective cohort studies were included.

High alcohol intake was significantly associated with increased risk of T2D (RR=1.16, 95% CI: 1.04–1.29; Q statistic p=0.326) compared to the lowest category of alcohol intake.

Nonlinear association was observed between alcohol consumption and T2D risk in men (p=0.003).

Dose-wise, consuming ≤57 g/day of alcohol was not associated with the risk of T2D in this study; however, alcohol intake >57 g/day was associated with increased risk of T2D in men.

Overall, the association between alcohol consumption and T2D among Asian men was J-shaped.

Lifestyle recommendations for prevention of T2D should include advice on limiting alcohol intake.

This trial is registered with Prospero registration: CRD 42019121073.