Comparing High-Intensity Interval Training (HIIT)‎ and Continuous Training on Apelin, APJ, NO, and Cardiotrophin-1 in Cardiac Tissue of Diabetic Rats

الملخص EN

Background and Aims.

Exercise activity is an important method for managing type 2 diabetes.

This investigation examined the HIIT and continuous training on apelin, APJ receptor, NO, and cardiotrophin-1 in the cardiac tissue of diabetic rats.

Methods.

The animals were categorized into 3 groups of HIIT, continuous (CO), and control (C) (all animals were sacrificed immediately and 2 days after exercise training period).

Rats underwent the treadmill exercise program either HIIT (12 bouts at 90–95% of VO2 max with 60 s rest at 50% of VO2 max) or CO (60–65% VO2 max for 40 min).

Protocols performed 5 days per week for 8 weeks.

Apelin, APJ receptor, NO, and cardiotrophin-1 protein expressions were measured using the Western blotting method in the left ventricle.

Results.

Immediately after HIIT and CO exercise protocols, apelin and CT-1 protein showed a significant difference in contrast by the C-0 group (p<0.01).

However, NO values were substantially higher in HIIT-0 compared to C-0 and CO-0 groups rats (p<0.01).

After two days of exercise protocols, apelin and NO protein showed a significant increase in HIIT and CO groups in contrast to the C animals (p<0.01).

Moreover, APJ and CT-1 protein significantly upregulated in CO-2 and HIIT-2 compared to the other groups (p<0.01).

Conclusions.

This study indicates that exercise training, despite the type, is an efficient method to modify apelin, APJ receptor, NO, and cardiotrophin-1 values in animals with type 2 diabetes.