Nanoencapsulation of Curcumin and Its Protective Effects against CCl4-Induced Hepatotoxicity in Mice

المؤلفون المشاركون

Shi, Ming
Li, Jian
Niu, Ruixu
Dong, Lixin
Gao, Liming
Zhang, Jie
Zheng, Yue
Liu, Zhiwei
Li, Kun

المصدر

Journal of Nanomaterials

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-02-04

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الكيمياء
هندسة مدنية

الملخص EN

Curcumin is a natural phenolic compound extracted from the herb Curcuma longa L.

rhizome and has received much attention on account of its biological properties.

However, its poor solubility and low bioavailability limit its use.

The purpose of this study was to synthesize curcumin-loaded nanoliposomes (Cur-NLs) to improve their bioavailability and evaluate the hepatoprotective effect of Cur-NLs against tetrachloromethane- (CCl4-) induced acute liver injury in mice.

We prepared Cur-NLs by thin film dispersion method, and the characterizations of Cur-NLs were measured by transmission microscope, laser particle size analyzer, infrared spectrometer, and X-ray diffraction.

After 14 days pretreatment of Cur-NLs, free curcumin, silybin, or PBS, the models of acute liver injury were established by CCl4 intraperitoneal injection in mice.

The organ index, biochemical liver function parameters, histopathology, and antioxidant enzyme activities of liver tissues were measured further to evaluate the protective effects of Cur-NLs on liver injury.

Compared with the CCl4 model control group, pretreatment of Cur-NLs effectively reduced the serum levels of ALT, AST, and ALP and attenuated the hepatic necrosis induced by CCl4 intoxication.

Furthermore, Cur-NL pretreatment remarkably exhibited decreased MDA level and increased SOD, GPx, and CAT activities compared to CCl4 model control group.

Compared with the free curcumin group, the Cur-NLs also showed a better hepatoprotective effect.

These observations imply that Cur-NLs act as a promising hepatoprotective agent in reducing liver oxidative stress produced by different stress factors.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Jian& Niu, Ruixu& Dong, Lixin& Gao, Liming& Zhang, Jie& Zheng, Yue…[et al.]. 2019. Nanoencapsulation of Curcumin and Its Protective Effects against CCl4-Induced Hepatotoxicity in Mice. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1182880

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Jian…[et al.]. Nanoencapsulation of Curcumin and Its Protective Effects against CCl4-Induced Hepatotoxicity in Mice. Journal of Nanomaterials No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1182880

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Jian& Niu, Ruixu& Dong, Lixin& Gao, Liming& Zhang, Jie& Zheng, Yue…[et al.]. Nanoencapsulation of Curcumin and Its Protective Effects against CCl4-Induced Hepatotoxicity in Mice. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1182880

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1182880