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Glucose-Regulated Protein 78 in the Aqueous Humor of Patients with Diabetic Macular Edema
المؤلفون المشاركون
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
We identified the associations between levels of aqueous glucose-regulated protein 78 (GRP78) and systemic or ocular factors in patients with center-involving diabetic macular edema (CIDME).
Methods.
We measured the aqueous concentrations of GRP78, interleukin- (IL-) 1β, IL-2, IL-8, IL-10, and IL-17, placental growth factor, and vascular endothelial growth factor (VEGF).
We explored the associations between aqueous GRP78 levels and those of other aqueous factors, optical coherence tomography (OCT) findings, and systemic parameters in CIDME patients.
Results.
In multivariate regression analysis, aqueous GRP78 levels were associated with aqueous VEGF levels (p=0.007), length of EZ disruption (p<0.001), and duration of diabetes (p=0.002).
However, no significant relationship was observed between GRP78 levels and those of other systemic and ocular factors including inflammatory cytokines in the aqueous humor.
In terms of responsiveness, the number of hyperreflective foci (≥8) was significantly associated with the responsiveness of three consecutive monthly intravitreal bevacizumab injections (OR=0.34, p=0.046), but not the aqueous GRP78 levels.
Conclusions.
Aqueous GRP78 levels correlated with VEGF levels in the aqueous humor and EZ disruption on OCT.
However, GRP78 levels were not associated with those of inflammatory biomarkers in the aqueous humor or OCT findings.
Additionally, GRP78 could not serve as a biomarker to predict short-term prognosis of anti-VEGF agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Moon Young& Kwon, Jin-woo. 2020. Glucose-Regulated Protein 78 in the Aqueous Humor of Patients with Diabetic Macular Edema. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1182892
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Moon Young& Kwon, Jin-woo. Glucose-Regulated Protein 78 in the Aqueous Humor of Patients with Diabetic Macular Edema. Journal of Diabetes Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1182892
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Moon Young& Kwon, Jin-woo. Glucose-Regulated Protein 78 in the Aqueous Humor of Patients with Diabetic Macular Edema. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1182892
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182892
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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