Serum Irisin Levels, Endothelial Dysfunction, and Inflammation in Pediatric Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome
المؤلفون المشاركون
Silva-Platas, Christian
Garcia-Rivas, Gerardo
Huerta-Delgado, Anna S.
Roffe-Vazquez, Daniel N.
Gonzalez-Gil, Adrian M.
Villarreal-Calderón, José R.
Tamez-Rivera, Oscar
Rodriguez-Gutierrez, Nora A.
Castillo, Elena C.
Elizondo-Montemayor, Leticia
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-07
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The prevalence of type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) has increased in the pediatric population.
Irisin, an adipomyokine, is involved in white adipose tissue browning, energy expenditure, insulin sensitivity, and anti-inflammatory pathways.
Data on the associations among circulating irisin levels, soluble cell adhesion molecules (sCAMs), and inflammatory cytokines is scarce in children and adolescents with MetS and T2DM.
Subjects aged 6-16 years were grouped into T2DM, MetS, and healthy controls.
Serum irisin levels were significantly lower in the MetS (6.6 [2.8-18.0] ng/mL) and T2DM (6.8 [2.2-23.2] ng/mL) groups compared with controls (30.3 [24.6-57.1] ng/mL).
Negative correlations between irisin and the BMI percentile (R=−0.358), WC percentile (R=−0.308), and triglycerides (R=−0.284) were identified, while positive associations with TC (R=0.287), HDL-c (R=0.488), and LDL-c (R=0.414) were observed.
Significant negative correlations were found between irisin and sNCAM (R=−0.382), sICAM-2 (R=−0.300), sVCAM-1 (R=−0.292), MCP-1 (R=−0.308), and IFN-α2 (R=−0.406).
Of note, lower concentrations of most sCAMs (sICAM-1, sPSGL-1, sP-selectin, sEpCAM, sICAM-2, sALCAM, sPECAM-1, sCD44, sVCAM-1, sICAM-3, sL-selectin, and sNCAM) were shown in T2DM subjects compared with MetS patients.
Lower irisin levels induce a lack of inhibition of oxidative stress and inflammation.
In T2DM, higher ROS, AGEs, glucotoxicity, and inflammation trigger endothelial cell apoptosis, which downregulates the sCAM expression as a compensatory mechanism to prevent further vascular damage.
In opposition, in subjects with MetS that have not yet developed T2DM and its accompanying stressors, the upregulation of the sCAM expression is ensued.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huerta-Delgado, Anna S.& Roffe-Vazquez, Daniel N.& Gonzalez-Gil, Adrian M.& Villarreal-Calderón, José R.& Tamez-Rivera, Oscar& Rodriguez-Gutierrez, Nora A.…[et al.]. 2020. Serum Irisin Levels, Endothelial Dysfunction, and Inflammation in Pediatric Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1182918
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huerta-Delgado, Anna S.…[et al.]. Serum Irisin Levels, Endothelial Dysfunction, and Inflammation in Pediatric Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome. Journal of Diabetes Research No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1182918
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huerta-Delgado, Anna S.& Roffe-Vazquez, Daniel N.& Gonzalez-Gil, Adrian M.& Villarreal-Calderón, José R.& Tamez-Rivera, Oscar& Rodriguez-Gutierrez, Nora A.…[et al.]. Serum Irisin Levels, Endothelial Dysfunction, and Inflammation in Pediatric Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1182918
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182918
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر