Selective Inhibition of PKCβ2 Restores Ischemic Postconditioning-Mediated Cardioprotection by Modulating Autophagy in Diabetic Rats
المؤلفون المشاركون
Wang, Yafeng
Zhou, Lu
Huang, Fengnan
Zhang, Yuan
Lei, Shao-Qing
Su, Wating
Xia, Zhengyuan
Xia, Zhong-Yuan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Diabetic hearts are more susceptible to myocardial ischemia/reperfusion (I/R) injury and less sensitive to ischemic postconditioning (IPostC), but the underlying mechanisms remain unclear.
PKCβ2 is preferentially overactivated in diabetic myocardium, in which autophagy status is abnormal.
This study determined whether hyperglycemia-induced PKCβ2 activation resulted in autophagy abnormality and compromised IPostC cardioprotection in diabetes.
We found that diabetic rats showed higher cardiac PKCβ2 activation and lower autophagy than control at baseline.
However, myocardial I/R further increased PKCβ2 activation and promoted autophagy status in diabetic rats.
IPostC significantly attenuated postischemic infarct size and CK-MB, accompanied with decreased PKCβ2 activation and autophagy in control but not in diabetic rats.
Pretreatment with CGP53353, a selective inhibitor of PKCβ2, attenuated myocardial I/R-induced infarction and autophagy and restored IPostC-mediated cardioprotection in diabetes.
Similarly, CGP53353 could restore hypoxic postconditioning (HPostC) protection against hypoxia reoxygenation- (HR-) induced injury evidenced by decreased LDH release and JC-1 monomeric cells and increased cell viability.
These beneficial effects of CGP53353 were reversed by autophagy inducer rapamycin, but could be mimicked by autophagy inhibitor 3-MA.
It is concluded that selective inhibition of PKCβ2 could attenuate myocardial I/R injury and restore IPostC-mediated cardioprotection possibly through modulating autophagy in diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yafeng& Zhou, Lu& Su, Wating& Huang, Fengnan& Zhang, Yuan& Xia, Zhong-Yuan…[et al.]. 2020. Selective Inhibition of PKCβ2 Restores Ischemic Postconditioning-Mediated Cardioprotection by Modulating Autophagy in Diabetic Rats. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1182947
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yafeng…[et al.]. Selective Inhibition of PKCβ2 Restores Ischemic Postconditioning-Mediated Cardioprotection by Modulating Autophagy in Diabetic Rats. Journal of Diabetes Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1182947
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yafeng& Zhou, Lu& Su, Wating& Huang, Fengnan& Zhang, Yuan& Xia, Zhong-Yuan…[et al.]. Selective Inhibition of PKCβ2 Restores Ischemic Postconditioning-Mediated Cardioprotection by Modulating Autophagy in Diabetic Rats. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1182947
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182947
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر