A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease
المؤلفون المشاركون
Lu, Xiaoguang
Liu, Tongtong
Yang, Liping
Wang, Yuyang
Mao, Huimin
Zhou, Weie
Li, Ping
Zhan, Yongli
Ma, Fang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-20
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
Diabetic kidney disease (DKD) poses a major public-health burden globally.
Tripterygium wilfordii Hook F (TwHF) is a widely employed herbal medicine in decreasing albuminuria among diabetic patients.
However, a holistic network pharmacology strategy to investigate the active components and therapeutic mechanism underlying DKD is still unavailable.
Methods.
We collected TwHF ingredients and their targets by traditional Chinese Medicine databases (TCMSP).
Then, we obtained DKD targets from GeneCards and OMIM and collected and analyzed TwHF-DKD common targets using the STRING database.
Protein-protein interaction (PPI) network was established by Cytoscape and analyzed by MCODE plugin to get clusters.
In addition, the cytoHubba software was used to identify hub genes.
Finally, all the targets of clusters were subjected for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses via DAVID.
Results.
A total of 51 active ingredients in TwHF were identified and hit by 88 potential targets related to DKD.
Compounds correspond to more targets include kaempferol, beta-sitosterol, stigmasterol, and Triptoditerpenic acid B, which appeared to be high-potential compounds.
Genes with higher degree including VEGFA, PTGS2, JUN, MAPK8, and HSP90AA1 are hub genes of TwHF against DKD, which are involved in inflammation, insulin resistance, and lipid homeostasis.
Kaempferol and VEGFA were represented as the uppermost active ingredient and core gene of TwHF in treating DKD, respectively.
DAVID results indicated that TwHF may play a role in treating DKD through AGE-RAGE signaling pathway, IL-17 signaling pathway, TNF signaling pathway, insulin resistance, and calcium signaling pathway (P<0.05).
Conclusion.
Kaempferol and VEGFA were represented as the uppermost active ingredient and core gene of TwHF in treating DKD, respectively.
The key mechanisms of TwHF against DKD might be involved in the reduction of renal inflammation by downregulating VEGFA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yuyang& Liu, Tongtong& Ma, Fang& Lu, Xiaoguang& Mao, Huimin& Zhou, Weie…[et al.]. 2020. A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1182949
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yuyang…[et al.]. A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease. Journal of Diabetes Research No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1182949
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yuyang& Liu, Tongtong& Ma, Fang& Lu, Xiaoguang& Mao, Huimin& Zhou, Weie…[et al.]. A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1182949
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182949
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر