Circulating T Cells Exhibit Different TIM3Galectin-9 Expression in Patients with Obesity and Obesity-Related Diabetes
المؤلفون المشاركون
Du, Xuan
Zhang, Xueguang
Sun, Lili
Ding, Sisi
Shen, Yu
Zou, Shengyi
Liu, Cuiping
Shi, Bimin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aims.
Obesity is highly associated with type 2 diabetes mellitus (T2DM).
The TIM3/galectin-9 pathway plays an important role in immune tolerance.
Herein, we aimed to investigate the expression of TIM3 and galectin-9 in peripheral blood and to evaluate their clinical significance in patients with obesity and obesity-related T2DM.
Methods.
We performed flow cytometry on peripheral blood samples from healthy donors (HC), patients with simple obesity (OB), and patients with obesity comorbid T2DM (OD).
The expression of TIM3 on CD3+, CD4+, and CD8+ T cells was determined.
The level of galectin-9 in plasma was detected by ELISA.
Results.
We demonstrated the enhancement of TIM3 on CD3+, CD4+, and CD8+ T cells in the OB group when compared with healthy controls, while it was decreased significantly in the OD group.
The TIM3+CD8+ T cells of the OB group were positively correlated with risk factors including BMI, body fat rate, and hipline.
The concentration of galectin-9 of the OD group in plasma was significantly higher than that of healthy donors and the OB group.
Moreover, the level of galectin-9 of the OD group was positively correlated with fasting insulin and C-peptide, which were two clinical features that represented pancreatic islet function in T2DM.
Conclusions.
Our results suggested that TIM3 and galectin-9 may be potential biomarkers related to the pathogenesis of obesity-related T2DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Lili& Zou, Shengyi& Ding, Sisi& Du, Xuan& Shen, Yu& Liu, Cuiping…[et al.]. 2020. Circulating T Cells Exhibit Different TIM3Galectin-9 Expression in Patients with Obesity and Obesity-Related Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1182965
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Lili…[et al.]. Circulating T Cells Exhibit Different TIM3Galectin-9 Expression in Patients with Obesity and Obesity-Related Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1182965
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Lili& Zou, Shengyi& Ding, Sisi& Du, Xuan& Shen, Yu& Liu, Cuiping…[et al.]. Circulating T Cells Exhibit Different TIM3Galectin-9 Expression in Patients with Obesity and Obesity-Related Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1182965
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1182965
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر