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Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity
المؤلفون المشاركون
Fascineli, Maria Luiza
Bentes de Azevedo, Ricardo
Joanitti, Graziella A.
Milhomem-Paixão, Susana Suely Rodrigues
Muehlmann, Luis Alexandre
Melo, Karina Motta
Salgado, Hugo Leonardo Crisóstomo
Pieczarka, Julio Cesar
Santos, Alberdan Silva
Grisolia, Cesar Koppe
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Andiroba oil (AO) is obtained from an Amazonian plant and is used in traditional medicine.
We carried out a comparative study to test the cytotoxicity, genotoxicity, and hematotoxicity of the oil and its nanoemulsion (AN) in vitro (fibroblasts, lineage NIH/3T3) and in vivo (Swiss mice).
The AN was characterized by DLS/Zeta, and its stability was investigated for 120 days.
The biological activity of AN was assessed in vitro by MTT test and cell morphology analyses and in vivo by micronucleus, comet, and hematotoxicity tests.
The AN presented a hydrodynamic diameter (Hd) of 142.5±3.0 and PDI of 0.272±0.007 and good stability at room temperature.
The MTT test evidenced the cytotoxicity of AO and of AN only at their highest concentrations, but AN showed lower cytotoxicity than AO.
A lower cytotoxicity of AN, when compared to AO, is in fact an interesting data suggesting that during therapeutic application there will be a lower impact in the cell viability of healthy cells.
Cytotoxicity, genotoxicity, and hematotoxicity were not observed in vivo.
These tests on the biological and toxicological effects of andiroba oil and nanostructured oil are still initial ones but will give a direction to future application in cosmetics and/or the development of new phytotherapics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Milhomem-Paixão, Susana Suely Rodrigues& Fascineli, Maria Luiza& Muehlmann, Luis Alexandre& Melo, Karina Motta& Salgado, Hugo Leonardo Crisóstomo& Joanitti, Graziella A.…[et al.]. 2017. Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1183018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Milhomem-Paixão, Susana Suely Rodrigues…[et al.]. Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity. Journal of Nanomaterials No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1183018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Milhomem-Paixão, Susana Suely Rodrigues& Fascineli, Maria Luiza& Muehlmann, Luis Alexandre& Melo, Karina Motta& Salgado, Hugo Leonardo Crisóstomo& Joanitti, Graziella A.…[et al.]. Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1183018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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