Hypoglycemia during Short-Term Intensive Insulin Therapy and Its Association with Long-Term Glycemic Remission in Patients with Newly Diagnosed Type 2 Diabetes
المؤلفون المشاركون
Liu, Juan
Li, Yanbing
Liu, Liehua
Zhang, Pengyuan
Huang, Zhimin
Xu, Lijuan
Zhong, Liangying
Li, Hai
Xiao, Haipeng
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Short-term intensive insulin therapy induces long-term glycemic remission in half of patients with newly diagnosed type 2 diabetes.
The concomitant hypoglycemia needs further analysis.
Methods.
We collected data from three randomized trials conducted with the same inclusion and exclusion criteria at our institution from 2002 to 2015.
Continuous subcutaneous insulin infusion (CSII) was provided to achieve the glycemic goals within a week and then maintained for 14 days.
Hypoglycemia episodes during short-term treatment and the one-year drug-free glycemic remission were observed.
Results.
A total of 244 patients were included.
The per day episode of mild hypoglycemia (3.0-3.9 mmol/L) was higher in the remission group than in the nonremission group (0.26±0.20 vs.
0.18±0.21, P=0.005).
However, a moderate hypoglycemia episode (<3.0 mmol/L) per day was insignificantly lower in the remission group (0.02±0.04 vs.
0.03±0.04, P=0.221).
After the cessation of insulin treatment, both acute insulin response (491.35 (801.89) vs.
370.22 (542.29), P=0.028) and homeostasis model assessment of insulin resistance (2.08 (2.04) vs.
2.48 (2.32), P=0.038) were more improved in the remission group than in the nonremission group.
Logistic regression analysis showed that mild hypoglycemic episodes during short-term CSII treatment were independently related to a long-term glycemic remission (OR=2.18, 95% CI 1.02~4.70).
Stratified analysis demonstrated that episodes during the continuing insulin dose reduction period played a substantial role.
Conclusions.
Mild hypoglycemic episodes during the continuing insulin dose reduction period indicate a long-term drug-free euglycemic remission in patients with newly diagnosed type 2 diabetes.
However, the insulin dosage should be reduced even more quickly in the future treatment to decrease the potential harms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Lijuan& Zhang, Pengyuan& Huang, Zhimin& Zhong, Liangying& Li, Hai& Liu, Liehua…[et al.]. 2020. Hypoglycemia during Short-Term Intensive Insulin Therapy and Its Association with Long-Term Glycemic Remission in Patients with Newly Diagnosed Type 2 Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1183103
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Lijuan…[et al.]. Hypoglycemia during Short-Term Intensive Insulin Therapy and Its Association with Long-Term Glycemic Remission in Patients with Newly Diagnosed Type 2 Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1183103
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Lijuan& Zhang, Pengyuan& Huang, Zhimin& Zhong, Liangying& Li, Hai& Liu, Liehua…[et al.]. Hypoglycemia during Short-Term Intensive Insulin Therapy and Its Association with Long-Term Glycemic Remission in Patients with Newly Diagnosed Type 2 Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1183103
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183103
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر