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Identification of Susceptibility Modules and Genes for Cardiovascular Disease in Diabetic Patients Using WGCNA Analysis
المؤلفون المشاركون
Zhao, Yi-Ming
Lou, Han-Yu
Liang, Weiwei
Sun, Fangfang
Shan, Lizhen
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
To identify susceptibility modules and genes for cardiovascular disease in diabetic patients using weighted gene coexpression network analysis (WGCNA).
Methods.
The raw data of GSE13760 were downloaded from the Gene Expression Omnibus (GEO) website.
Genes with a false discovery rate<0.05 and a log2 fold change≥0.5 were included in the analysis.
WGCNA was used to build a gene coexpression network, screen important modules, and filter the hub genes.
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed for the genes in modules with clinical interest.
Genes with a significance over 0.2 and a module membership over 0.8 were used as hub genes.
Subsequently, we screened these hub genes in the published genome-wide SNP data of cardiovascular disease.
The overlapped genes were defined as key genes.
Results.
Fourteen gene coexpression modules were constructed via WGCNA analysis.
Module greenyellow was mostly significantly correlated with diabetes.
The GO analysis showed that genes in the module greenyellow were mainly enriched in extracellular matrix organization, extracellular exosome, and calcium ion binding.
The KEGG analysis showed that the genes in the module greenyellow were mainly enriched in antigen processing and presentation, phagosome.
Fifteen genes were identified as hub genes.
Finally, HLA-DRB1, LRP1, and MMP2 were identified as key genes.
Conclusion.
This was the first study that used the WGCNA method to construct a coexpression network to explore diabetes-associated susceptibility modules and genes for cardiovascular disease.
Our study identified a module and several key genes that acted as essential components in the etiology of diabetes-associated cardiovascular disease, which may enhance our fundamental knowledge of the molecular mechanisms underlying this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Weiwei& Sun, Fangfang& Zhao, Yi-Ming& Shan, Lizhen& Lou, Han-Yu. 2020. Identification of Susceptibility Modules and Genes for Cardiovascular Disease in Diabetic Patients Using WGCNA Analysis. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1183119
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Weiwei…[et al.]. Identification of Susceptibility Modules and Genes for Cardiovascular Disease in Diabetic Patients Using WGCNA Analysis. Journal of Diabetes Research No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1183119
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Weiwei& Sun, Fangfang& Zhao, Yi-Ming& Shan, Lizhen& Lou, Han-Yu. Identification of Susceptibility Modules and Genes for Cardiovascular Disease in Diabetic Patients Using WGCNA Analysis. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1183119
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183119
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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