The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism
المؤلفون المشاركون
Li, Hong
Tang, Shengjie
Wu, Fang
Lin, Xihua
Gui, Weiwei
Zheng, Fenping
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the control of lipid homeostasis.
Here, we investigated the effects of CP775146, a new selective PPARα agonist, on lipid metabolism in diet-induced obese mice and its possible mechanism.
Methods.
C57BL/6 mice were fed a high-fat diet (HFD) for 12 weeks to induce obesity and then received CP775146 via intraperitoneal injection for 3 days.
The content/morphology of the liver, serum lipid, and liver function was measured.
The expression of genes related to lipolysis and synthesis in liver was detected by quantitative real-time PCR (qRT-PCR).
Results.
The safe dose of CP775146 was <0.3 mg/kg.
CP775146 reduced the serum levels of liver enzymes, such as alanine aminotransferase (ALT) and glutamic-oxaloacetic transaminase (AST) and lipid metabolism-related biomarkers, including triglycerides (TGs) and low-density lipoprotein cholesterol (LDL-c), non-high-density lipoprotein cholesterol (non-HDL-c), and hepatic TG content, at a dosage of 0.1 mg/kg.
HFD-induced pathological liver changes improved after CP775146 treatment.
The expression of genes involved in liver fatty acid oxidation (acyl-coenzyme A dehydrogenase, long chain (Acadl), acyl-CoA oxidase 1 (Acox-1), carnitine palmitoyltransferase-1 (CPT-1), and enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (Ehhadh)) was upregulated in CP775146-treated mice.
Furthermore, CP775146 induced the expression of thermogenesis genes (cell death-inducing DFFA-like effector a (Cidea), uncoupling protein 1 (Ucp1)) and lipolysis genes (hormone-sensitive lipase (Hsl), adipose tissue triglyceride lipase (Atgl)) in epididymal white adipose tissue (eWAT), activating browning and thermogenesis.
Conclusion.
CP775146 efficiently alleviates obesity-induced liver damage, prevents lipid accumulation by activating the liver fatty acid β-oxidation pathway, and regulates the expression of genes that control brown fat-like pathway in eWAT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Shengjie& Wu, Fang& Lin, Xihua& Gui, Weiwei& Zheng, Fenping& Li, Hong. 2020. The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183121
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Shengjie…[et al.]. The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism. Journal of Diabetes Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1183121
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Shengjie& Wu, Fang& Lin, Xihua& Gui, Weiwei& Zheng, Fenping& Li, Hong. The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183121
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183121
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر