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Lactobacillus plantarum And Inulin: Therapeutic Agents to Enhance Cardiac Ob Receptor Expression and Suppress Cardiac Apoptosis in Type 2 Diabetic Rats
المؤلفون المشاركون
Sefidgari-Abrasi, Safa
Karimi, Pouran
Roshangar, Leila
Morshedi, Mohammad
Bavafa-Valenlia, Khadijeh
Saghafi-Asl, Maryam
Mohiti, Sara
Rahimiyan-Heravan, Marziyeh
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-16
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
T2DM may cause increased levels of oxidative stress and cardiac apoptosis through elevated blood glucose.
The present study investigated the effects of Lactobacillus plantarum (L.
plantarum) as a probiotic strain and inulin as a prebiotic supplement on cardiac oxidative stress and apoptotic markers in type 2 diabetes mellitus (T2DM) rats.
Methods.
A high-fat diet and a low dose of streptozotocin were used to induce type 2 diabetes.
The rats were divided into six groups which were supplemented with L.
plantarum, inulin, or their combination for 8 weeks.
Results.
The results showed improved activity of cardiac antioxidant parameters including total antioxidant capacity (TAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) (P<0.001, P<0.01, and P<0.01, respectively) and decreased level of cardiac malondialdehyde (MDA) concentration (P<0.05).
These changes were accompanied with increased protein expression of cardiac obesity receptor (Ob-R) (P=0.05) and reduced apoptotic markers such as tumor necrosis factor-alpha (TNF-α), Fas ligand (FasL), and caspase proteins (P<0.001, P=0.003, and P<0.01, respectively) in T2DM rats after concurrent L.
plantarum and inulin supplementation.
Moreover, a remarkable correlation of cardiac Ob-R and oxidative stress parameters with cardiac apoptotic markers was observed (P<0.01).
Conclusion.
The concurrent use of L.
plantarum and inulin seems to be beneficial, as they can lead to decreased heart complications of T2DM via reducing cardiac apoptotic markers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sefidgari-Abrasi, Safa& Karimi, Pouran& Roshangar, Leila& Morshedi, Mohammad& Bavafa-Valenlia, Khadijeh& Saghafi-Asl, Maryam…[et al.]. 2020. Lactobacillus plantarum And Inulin: Therapeutic Agents to Enhance Cardiac Ob Receptor Expression and Suppress Cardiac Apoptosis in Type 2 Diabetic Rats. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1183152
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sefidgari-Abrasi, Safa…[et al.]. Lactobacillus plantarum And Inulin: Therapeutic Agents to Enhance Cardiac Ob Receptor Expression and Suppress Cardiac Apoptosis in Type 2 Diabetic Rats. Journal of Diabetes Research No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1183152
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sefidgari-Abrasi, Safa& Karimi, Pouran& Roshangar, Leila& Morshedi, Mohammad& Bavafa-Valenlia, Khadijeh& Saghafi-Asl, Maryam…[et al.]. Lactobacillus plantarum And Inulin: Therapeutic Agents to Enhance Cardiac Ob Receptor Expression and Suppress Cardiac Apoptosis in Type 2 Diabetic Rats. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1183152
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183152
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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