Biocompatibility and Toxicity of Polylactic AcidFerrosoferric Oxide Nanomagnetic Microsphere

الملخص EN

Magnetic targeted drugs delivery system (MTDDS) is a new targeted drug system, which can greatly reduce the dosage and improve the therapeutic efficiency of medicine.

Currently superparamagnetic ferric oxide plays important function as targeted drug in the treatment of tumors, but cytotoxicity was still regarded as side effect in the process of drug.

In this paper, we take advantage of drug carrier (ferric oxide) toxicity controlling cancer cell growth in cancer treatment, increasing targeted drug efficiency.

We applied the modified chemical precipitation method to prepare polylactic acid (PLA) coated high-purity superparamagnetic Fe3O4 nanoparticles for targeted drug, characterized PLA/Fe3O4 microspheres physical and chemical properties, and then investigated cytotoxicity influence of PLA/Fe3O4 nanomagnetic microspheres as carrier for normal liver cells (7701) and liver cancer cells (HePG2) in different concentration; results of MTT and hemolysis and micronucleus test showed that carrier restrained the growth of HePG2 in special concentration, meanwhile the proliferation rate of liver cells was not affected.

The study demonstrates that compared with liver cell, liver cancer cells (HepG2) are easy to be disturbed by PLA/Fe3O4 nanomagnetic microsphere, which have higher sensitivity and absorption ability.

We hope to take advantage of the susceptible property of cancer cells for carriers to improve targeted drug function.