Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies
المؤلفون المشاركون
Xing, Yuling
Ma, Huijuan
Li, Xiaoli
Li, Lianju
Cheng, Tiantian
Ren, Shaohui
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Aims.
Although several epidemiological studies have investigated the relationship between diabetes mellitus (DM) and the risk of gout, the results are inconsistent.
Therefore, we systematically retrospected available observational studies to clarify the impact of DM on the risk of gout.
Methods.
Embase, PubMed, Cochrane Library, Scopus, Web of Science, and China National Knowledge Infrastructure were searched for relevant articles from inception to 2 March 2020.
The quality of the included studies was assessed using the Newcastle-Ottawa Quality Assessment Scale.
The multivariate adjusted relative risks (aRR) and corresponding 95% confidence intervals (CI) were pooled based on a random-effect model.
Cochran’s Q test and I2 were used to evaluate heterogeneity.
Results.
Five studies involving 863,755 participants were included in our meta-analysis.
DM was associated with a lower risk of gout (aRR: 0.66; 95% CI: 0.59 to 0.73) but had a high heterogeneity (I2=89.2%).
Metaregression analysis revealed that the types of DM were the source of heterogeneity.
Subgroup analysis by types of DM showed that the risk of gout was significantly lower in type 1 DM (T1DM) (aRR: 0.42; 95% CI: 0.28 to 0.63) than in type 2 DM (T2DM) (aRR: 0.72; 95% CI: 0.70 to 0.74).
Furthermore, when stratified according to gender in DM, sex-specific association was found.
The inverse association was observed in males only (aRR: 0.57; 95% CI: 0.43 to 0.77) and not in females (aRR: 0.96; 95% CI: 0.87 to 1.05).
Further stratified based on glycated hemoglobin (HbA1c) levels in DM, raised A1C levels were associated with a reduced risk of gout in patients with DM.
Conclusions.
This meta-analysis indicated that DM was related to a lower risk of gout, and the protective effect of DM on the risk of gout was stronger in males, T1DM, or DM with high HbA1c levels.
However, more prospective cohort studies are required to confirm these results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiaoli& Li, Lianju& Xing, Yuling& Cheng, Tiantian& Ren, Shaohui& Ma, Huijuan. 2020. Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183212
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiaoli…[et al.]. Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies. Journal of Diabetes Research No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1183212
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiaoli& Li, Lianju& Xing, Yuling& Cheng, Tiantian& Ren, Shaohui& Ma, Huijuan. Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1183212
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183212
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر