Effects of Newer Antidiabetic Drugs on Endothelial Function and Arterial Stiffness: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Thanopoulou, Anastasia
Noutsou, Marina
Batzias, Konstantinos
Antonopoulos, Alexios S.
Oikonomou, Evangelos
Bletsa, Evanthia
Stampouloglou, Panagiota K.
Mistakidi, Chara-Vasiliki
Karopoulos, Periklis
Charalambous, Georgios
Siassos, Gerassimos
Katsiki, N.
Tousoulis, Dimitris
Tentolouris, Nicholas
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Newer antidiabetic drugs, i.e., dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose cotransporter-2 (SGLT-2) inhibitors, and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may exert distinct cardiovascular effects.
We sought to explore their impact on vascular function.
Methods.
Published literature was systematically searched up to January 2018 for clinical studies assessing the effects of DPP-4 inhibitors, GLP-1 RAs, and SGLT-2 inhibitors on endothelial function and arterial stiffness, assessed by flow-mediated dilation (FMD) of the brachial artery and pulse wave velocity (PWV), respectively.
For each eligible study, we used the mean difference (MD) with 95% confidence intervals (CIs) for FMD and PWV.
The pooled MD for FMD and PWV were calculated by using a random-effect model.
The presence of heterogeneity among studies was evaluated by the I2 statistic.
Results.
A total of 26 eligible studies (n=668 patients) were included in the present meta-analysis.
Among newer antidiabetic drugs, only SGLT-2 inhibitors significantly improved FMD (pooled MD 1.14%, 95% CI: 0.18 to 1.73, p=0.016), but not DPP-4 inhibitors (pooled MD = 0.86%, 95% CI: -0.15 to 1.86, p=0.095) or GLP-1 RA (pooled MD = 2.37%, 95% CI: -0.51 to 5.25, p=0.107).
Both GLP-1 RA (pooled MD = −1.97, 95% CI: -2.65 to -1.30, p<0.001) and, to a lesser extent, DPP-4 inhibitors (pooled MD = -0.18, 95% CI: -0.30 to -0.07, p=0.002) significantly decreased PWV.
Conclusions.
Newer antidiabetic drugs differentially affect endothelial function and arterial stiffness, as assessed by FMD and PWV, respectively.
These findings could explain the distinct effects of these drugs on cardiovascular risk of patients with type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Batzias, Konstantinos& Antonopoulos, Alexios S.& Oikonomou, Evangelos& Siassos, Gerassimos& Bletsa, Evanthia& Stampouloglou, Panagiota K.…[et al.]. 2018. Effects of Newer Antidiabetic Drugs on Endothelial Function and Arterial Stiffness: A Systematic Review and Meta-Analysis. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1183243
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Batzias, Konstantinos…[et al.]. Effects of Newer Antidiabetic Drugs on Endothelial Function and Arterial Stiffness: A Systematic Review and Meta-Analysis. Journal of Diabetes Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1183243
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Batzias, Konstantinos& Antonopoulos, Alexios S.& Oikonomou, Evangelos& Siassos, Gerassimos& Bletsa, Evanthia& Stampouloglou, Panagiota K.…[et al.]. Effects of Newer Antidiabetic Drugs on Endothelial Function and Arterial Stiffness: A Systematic Review and Meta-Analysis. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1183243
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183243
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر