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Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity
المؤلفون المشاركون
Oka, Rie
Sakurai, Masaru
Kometani, Mitsuhiro
Yoshimura, Kenichi
Yoneda, Takashi
Wakabayashi, Yusuke
Karashima, Shigehiro
Sugihara, Masako
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Individuals with multiple metabolic risk factors often experience concomitant sleep-disordered breathing (SDB).
We aimed to determine the associations of SDB with individual components of metabolic syndrome independent of obesity.
Methods.
A cross-sectional study was conducted in 1137 employees aged 30–64 years.
Apnea-hypopnea index (AHI) was assessed using a portable monitor for obstructive sleep apnea by admission.
Of these, 451 participants took an oral glucose tolerance test to assess homeostatic model assessment of insulin resistance (HOMA-IR) and Matsuda insulin sensitivity index (ISI).
Results.
The odds ratio (OR) of the highest category of the AHI (≥15 episodes per hour) compared to the lowest one (<5 episodes per hour) was significantly elevated for hypertension, for hypertriglyceridemia, and for low HDL-cholesterolemia when adjusted for age, sex, and alcohol and smoking status (p<0.05).
After further adjustment for body mass index (BMI) or waist circumference, the associations for hypertension still remained statistically significant (p<0.05) while those for hypertriglyceridemia and low HDL-cholesterolemia were no longer significant.
The association between higher insulin resistance as assessed by HOMA-IR and Matsuda ISI and higher categories of the AHI was also lost after adjustment for BMI.
Conclusion.
Obesity was a strong confounding factor in the association between SDB and most metabolic risk factors including insulin resistance, except for hypertension.
Further longitudinal study is needed to examine the temporal or causal relationships between SDB and metabolic risk factors.
This trial is registered with UMIN-CTR UMIN000028067.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wakabayashi, Yusuke& Oka, Rie& Sugihara, Masako& Karashima, Shigehiro& Kometani, Mitsuhiro& Sakurai, Masaru…[et al.]. 2018. Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1183275
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wakabayashi, Yusuke…[et al.]. Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity. Journal of Diabetes Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1183275
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wakabayashi, Yusuke& Oka, Rie& Sugihara, Masako& Karashima, Shigehiro& Kometani, Mitsuhiro& Sakurai, Masaru…[et al.]. Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1183275
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183275
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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