Qatari Genotype May Contribute to Complications in Type 2 Diabetes
المؤلفون المشاركون
Butler, Alexandra E.
Dargham, Soha R.
Robay, Amal
Crystal, Ronald G.
Dakroury, Youssra
Atkin, Stephen L.
Rodriguez-Flores, Juan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-10
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications.
Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East population may be contributory.
Therefore, three genotype-based Qatari ancestral groups, Q1 Arab Bedouin, Q2 Asian/Persian, and Q3 sub-Saharan African, with a fourth admixed group were correlated with T2DM prevalence and its complications to determine if they differed between the 4 Qatari ancestries, particularly for the SLMAP allele-associated diabetic retinopathy.
Methods.
In this cross-sectional study, 398 Qatari subjects, 220 with and 178 without T2DM, were genotyped by Affymetrix 500k SNP arrays.
Ancestry was correlated with diabetes complications.
Results.
398 subjects were included, the mean age was 49.8 years, and 56.8% were male.
The genotype-based ancestry and T2DM prevalence were as follows: 164 (41.2%) with ancestry Q1, 60.4% with T2DM; 149 (37.4%) with ancestry Q2, 49.7% with T2DM; 31 (7.8%) with ancestry Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed” ancestry, 51.9% with T2DM.
For patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in the Q3 ancestry.
Conclusion.
These data suggest that the genotype may contribute to complication risk, as exemplified by the increase in hypertension and retinopathy in the Q3 ancestry, though the SLMAP allele was not implicated; however, diabetes prevalence did not differ between the four Qatari ancestries.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dakroury, Youssra& Atkin, Stephen L.& Dargham, Soha R.& Robay, Amal& Rodriguez-Flores, Juan& Crystal, Ronald G.…[et al.]. 2020. Qatari Genotype May Contribute to Complications in Type 2 Diabetes. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183277
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dakroury, Youssra…[et al.]. Qatari Genotype May Contribute to Complications in Type 2 Diabetes. Journal of Diabetes Research No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1183277
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dakroury, Youssra& Atkin, Stephen L.& Dargham, Soha R.& Robay, Amal& Rodriguez-Flores, Juan& Crystal, Ronald G.…[et al.]. Qatari Genotype May Contribute to Complications in Type 2 Diabetes. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1183277
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183277
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر