Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats
المؤلفون المشاركون
Buabeid, Manal Ali
Arafa, El-Shaimaa A.
Hassan, Waseem
Murtaza, Ghulam
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Obesity linked diabetes, popularly known as diabesity, has been viewed as a direct product of the modern lifestyle in both developed and developing countries, and its increased prevalence is seen as a major threat to public health globally.
Ficus carica (FC) and Syzigium cumini (SC) are part of indigenous flora with traditional medicinal properties.
Fresh seeds of SC fruit and fruit of FC were collected and macerated to obtain the final extract.
Wistar rats were divided into seven groups fed either on a normal diet or high-fat diet (HFD) along with streptozocin (STZ) to induce diabesity.
The crude extract of FC (FC.Cr.) and SC (SC.Cr.) were administered at 250 mg/kg/day and 500 mg/kg/day in induced diabesity state.
Body weights, blood glucose level, complete blood count (CBC), cholesterol, triglycerides (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) were recorded to analyze their effects on glucose and lipid metabolism.
Further, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured to examine their effects on lipid peroxidation and ant oxidative enzyme.
Results showed that both FC.Cr.
and SC.Cr.
have the potential to control obesity-linked type 2 diabetes mellitus (T2DM) by lowering the body weights, serum glucose, cholesterol, TG, LDL, and VLDL, while increasing the protective effects of HDL dose-dependently.
The crude extract of both plants showed significant activity to raise SOD and curb MDA under diabetic states.
It was concluded that both FC.Cr.
and SC.Cr.
exhibited remarkable therapeutics potential in HFD-STZ-induced diabetic rats.
However, we found that the effects of SC.Cr.
are relatively more pronounced as compared to FC.Cr.
in almost all parameters.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arafa, El-Shaimaa A.& Hassan, Waseem& Murtaza, Ghulam& Buabeid, Manal Ali. 2020. Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183304
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arafa, El-Shaimaa A.…[et al.]. Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats. Journal of Diabetes Research No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1183304
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arafa, El-Shaimaa A.& Hassan, Waseem& Murtaza, Ghulam& Buabeid, Manal Ali. Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1183304
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183304
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر