Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the Confounding Effect of Antidiabetic Agents
المؤلفون المشاركون
Almugadam, Babiker Saad
Liu, Yinhui
Chen, Shen-min
Wang, Chun-hao
Shao, Chen-yi
Ren, Bao-wei
Tang, Li
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-28
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Type 2 diabetes is a leading cause of morbidity and a common risk of several disorders.
Identifying the microbial ecology changes is essential for disease prediction, therapy, and prevention.
Thus, our study is aimed at investigating the intestinal microbiota among healthy and type 2 diabetes individuals and exploring the effect of antidiabetic agents on gut bacterial flora.
24 type 2 diabetes (metformin, glimepiride, and nontherapeutic subgroups; N=8) and 24 healthy control subjects were enrolled in this study, and intestinal bacterial microbiota was investigated by analyzing V3-V4 regions of 16S rRNA gene sequence.
Numerous alterations were observed in the gut microbial community of diabetic individuals.
These changes were characterized by a significant lowered abundance of Faecalibacterium, Fusobacterium, Dialister, and Elusimicrobium in the nontherapeutic subgroup compared to the healthy control group.
Likewise, correlation analysis showed a substantial decline in gut microbiota richness and diversity with the duration of illness.
Furthermore, antidiabetic agents restored to some extent the richness and diversity of gut microbiota and improved the abundance of many beneficial bacteria with a significant increase of Methanobrevibacter in the metformin subcategory compared to the nontherapeutic subgroup.
In return, they decreased the abundance of some opportunistic pathogens.
The findings of this study have added a novel understanding about the pathogenesis of the disease and the mechanisms underlying antidiabetic therapy, which are of potential interest for therapeutic lines and further studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Almugadam, Babiker Saad& Liu, Yinhui& Chen, Shen-min& Wang, Chun-hao& Shao, Chen-yi& Ren, Bao-wei…[et al.]. 2020. Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the Confounding Effect of Antidiabetic Agents. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1183360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Almugadam, Babiker Saad…[et al.]. Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the Confounding Effect of Antidiabetic Agents. Journal of Diabetes Research No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1183360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Almugadam, Babiker Saad& Liu, Yinhui& Chen, Shen-min& Wang, Chun-hao& Shao, Chen-yi& Ren, Bao-wei…[et al.]. Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the Confounding Effect of Antidiabetic Agents. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1183360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر