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Association of Metformin Treatment with Reduced Severity of Diabetic Retinopathy in Type 2 Diabetic Patients
المؤلفون المشاركون
Ryu, Christina L.
Edwards, Paul
Gao, Hua
Li, Yue
Munie, Metasebia
Noorulla, Salma
Rana, Satyesh
Qiao, Xiaoxi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate effects of long-term metformin on the severity of diabetic retinopathy (DR) in high-risk type 2 diabetic (T2D) patients.
Methods.
A retrospective chart review study was conducted involving 335 DR patients with T2D ≥ 15 years from 1990 to 2013.
The severity of DR was determined by Early Treatment Diabetic Retinopathy Study scale.
The associations between metformin and DR severity were evaluated.
Comparison with stratification for the use of sulfonylurea and insulin was performed to identify possible confounding effects.
Results.
Severe nonproliferative diabetic retinopathy or proliferative diabetic retinopathy (SNPDR/PDR) was more often diagnosed in nonmetformin users (67/142, 47%) versus metformin users (48/193, 25%) (p<0.001), regardless of gender and race of the patients.
The odds ratio of metformin associated with SNPDR/PDR was 0.37 in all cases (p<0.001), 0.35 in sulfonylurea use cohort (p<0.05), 0.45 in nonsulfonylurea use cohorts (p<0.01), and 0.42 in insulin use cohort (p<0.01).
Insulin users had a higher rate of SNPDR/PDR.
Metformin had no influence on the occurrence of clinical significant diabetic macular edema.
Conclusions.
Long-term use of metformin is independently associated with a significant lower rate of SNPDR/PDR in patients with type 2 diabetes ≥ 15 years.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yue& Ryu, Christina L.& Munie, Metasebia& Noorulla, Salma& Rana, Satyesh& Edwards, Paul…[et al.]. 2018. Association of Metformin Treatment with Reduced Severity of Diabetic Retinopathy in Type 2 Diabetic Patients. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183386
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yue…[et al.]. Association of Metformin Treatment with Reduced Severity of Diabetic Retinopathy in Type 2 Diabetic Patients. Journal of Diabetes Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1183386
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yue& Ryu, Christina L.& Munie, Metasebia& Noorulla, Salma& Rana, Satyesh& Edwards, Paul…[et al.]. Association of Metformin Treatment with Reduced Severity of Diabetic Retinopathy in Type 2 Diabetic Patients. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183386
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183386
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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