Investigation of Various Cross-Linking Methods for the Immobilization of Cytosine Arabinoside on Bacterial Magnetosomes

المؤلفون المشاركون

Dai, Qinglei
Ma, Yiming
Wang, Shibin
Kankala, Ranjith Kumar
Liu, Yuangang

المصدر

Journal of Nanomaterials

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-05-22

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الكيمياء
هندسة مدنية

الملخص EN

Bacterial magnetosomes (BMs) have emerged as potential drug delivery vehicles, possessing an iron oxide or iron sulfide core surrounded by a natural lipid membrane shell.

In this study, we immobilized cytosine arabinoside (Ara-C) effectively on BMs by using various methods such as direct absorption (ABMs), and others include different cross-linkers such as genipin (GP) and glutaraldehyde (G).

A well-dispersed Ara-C coupled bacterial magnetosomes resulted in significantly higher negative charge than that of naked BMs (−11.5±0.3 mV) confirming the drug loading.

Out of all methods, direct absorption process led to the highest encapsulation efficiency and drug loading of 88.2±4.3% and 46.9±1.2%, respectively.

These designs have shown the long-term drug release behavior without an initial burst release.

Our results indicate that BMs-based nanoconjugates will potentially find widespread applications in pharmaceutical field.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Dai, Qinglei& Ma, Yiming& Wang, Shibin& Kankala, Ranjith Kumar& Liu, Yuangang. 2017. Investigation of Various Cross-Linking Methods for the Immobilization of Cytosine Arabinoside on Bacterial Magnetosomes. Journal of Nanomaterials،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1183405

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Dai, Qinglei…[et al.]. Investigation of Various Cross-Linking Methods for the Immobilization of Cytosine Arabinoside on Bacterial Magnetosomes. Journal of Nanomaterials No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1183405

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Dai, Qinglei& Ma, Yiming& Wang, Shibin& Kankala, Ranjith Kumar& Liu, Yuangang. Investigation of Various Cross-Linking Methods for the Immobilization of Cytosine Arabinoside on Bacterial Magnetosomes. Journal of Nanomaterials. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1183405

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1183405