The Usefulness of Genotyping of Celiac Disease-Specific HLA among Children with Type 1 Diabetes in Various Clinical Situations
المؤلفون المشاركون
Deja, Grazyna
Jarosz-Chobot, Przemyslawa
Sikora, Dominika
Pyziak-Skupien, Aleksandra
Klenczar, Karolina
Deja, Rafał
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
The aim of the study was to determine the usefulness of HLA DQ2/DQ8 genotyping in children with T1D in various clinical situations: as a screening test at the diabetes onset, as a verification of the diagnosis in doubtful situations, and as a test estimating the risk of CD in the future.
Materials and methods.
Three groups of patients with T1D were included: newly diagnosed (n=92), with CD and villous atrophy (n=30), and with potential CD (n=23).
Genetic tests were performed (commercial test, PCR, and REX), and clinical data were collected.
Results.
The results of genetic tests confirmed the presence of DQ2/DQ8 in 94% of children with diabetes (group I) and in 100% of children with diabetes and CD (groups II and III, respectively).
Comparative analysis of the HLA DQ2/DQ8 distribution did not show any differences.
Allele DRB1∗04 (linked with HLA DQ8) was significantly less common in children with diabetes and CD (group I versus groups II and III, 56.5% vs.
24.5%; p=0.001).
The probability of developing CD in DRB1∗04-positive patients was 4 times lower (OR 0.25; 95% CI 0.118-0.529; p=0.001).
DRB1∗04 was significantly less frequent in children with villous atrophy compared to potential CD (13% vs.
39%; p=0.03).
Conclusions.
Genotyping HLA DQ2/DQ8 as a negative screening has limited use in assessing the risk of CD at the diabetes onset and does not allow to verify the diagnosis of CD in doubtful situations.
The presence of the DRB1∗04 allele modulates the risk of CD and significantly reduces it and can predict a potential form.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deja, Grazyna& Sikora, Dominika& Pyziak-Skupien, Aleksandra& Klenczar, Karolina& Deja, Rafał& Jarosz-Chobot, Przemyslawa. 2020. The Usefulness of Genotyping of Celiac Disease-Specific HLA among Children with Type 1 Diabetes in Various Clinical Situations. Journal of Diabetes Research،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1183421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deja, Grazyna…[et al.]. The Usefulness of Genotyping of Celiac Disease-Specific HLA among Children with Type 1 Diabetes in Various Clinical Situations. Journal of Diabetes Research No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1183421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deja, Grazyna& Sikora, Dominika& Pyziak-Skupien, Aleksandra& Klenczar, Karolina& Deja, Rafał& Jarosz-Chobot, Przemyslawa. The Usefulness of Genotyping of Celiac Disease-Specific HLA among Children with Type 1 Diabetes in Various Clinical Situations. Journal of Diabetes Research. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1183421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر