Evaluation of Aldose Reductase, Protein Glycation, and Antioxidant Inhibitory Activities of Bioactive Flavonoids in Matricaria recutita L. and Their Structure-Activity Relationship
المؤلفون المشاركون
Lim, Soon Sung
Hwang, Seung Hwan
Wang, Zhiqiang
Guillen Quispe, Yanymee N.
Yu, Jae Myung
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The inhibitory activities of Matricaria recutita L.
70% methanol extract were evaluated by isolating and testing 10 of its compounds on rat lens aldose reductase (RLAR), advanced glycation end products (AGEs), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging.
Among these compounds, apigenin-7-O-β-D-glucoside, luteolin-7-O-β-D-glucoside, apigenin-7-O-β-D-glucuronide, luteolin-7-O-β-D-glucuronide, 3,5-O-di-caffeoylquinic acid, apigenin, and luteolin showed potent inhibition, and their IC50 values in RLAR were 4.25, 1.12, 1.16, 0.85, 0.72, 1.72, and 1.42 μM, respectively.
Furthermore, these compounds suppressed sorbitol accumulation in rat lens under high-glucose conditions, demonstrating their potential to prevent sorbitol accumulation ex vivo.
Notably, luteolin-7-O-β-D-glucuronide and luteolin showed antioxidative as well as AGE-inhibitory activities (IC50 values of these compounds in AGEs were 3.39 and 6.01 μM).
These results suggest that the M.
recutita extract and its constituents may be promising agents for use in the prevention or treatment of diabetic complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hwang, Seung Hwan& Wang, Zhiqiang& Guillen Quispe, Yanymee N.& Lim, Soon Sung& Yu, Jae Myung. 2018. Evaluation of Aldose Reductase, Protein Glycation, and Antioxidant Inhibitory Activities of Bioactive Flavonoids in Matricaria recutita L. and Their Structure-Activity Relationship. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183440
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hwang, Seung Hwan…[et al.]. Evaluation of Aldose Reductase, Protein Glycation, and Antioxidant Inhibitory Activities of Bioactive Flavonoids in Matricaria recutita L. and Their Structure-Activity Relationship. Journal of Diabetes Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1183440
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hwang, Seung Hwan& Wang, Zhiqiang& Guillen Quispe, Yanymee N.& Lim, Soon Sung& Yu, Jae Myung. Evaluation of Aldose Reductase, Protein Glycation, and Antioxidant Inhibitory Activities of Bioactive Flavonoids in Matricaria recutita L. and Their Structure-Activity Relationship. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183440
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183440
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر