Long-Term Provision of Acidified Drinking Water Fails to Influence Autoimmune Diabetes and Encephalomyelitis
المؤلفون المشاركون
Jayaraman, Sundararajan
Jayaraman, Arathi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Induction of autoimmune diseases is predisposed by background genetics and influenced by environmental factors including diet and infections.
Since consumption of acidified drinking water leads to eradication of gastrointestinal pathogens in animals, we tested whether it may also influence the development of autoimmune diseases.
The frequency of spontaneously occurring type 1 diabetes in female NOD mice that were maintained on acidified drinking water by the vendor did not alter after switching to neutral water in our facility.
In addition, experimentally induced autoimmune encephalomyelitis was also unaffected by the pH of the drinking water.
Interestingly, administration of complete Freund’s adjuvant alone or emulsified with a neuronal peptide to induce neurodegenerative disease during the prediabetic stage completely prevented the onset of diabetes regardless of the pH of the drinking water.
However, exposure to microbial products later in life had only a partial blocking effect on diabetes induction, which was also not influenced by the ionic content of the drinking water.
Taken together, these data indicate that the onset of autoimmune diseases is not influenced by the gastrointestinal pathogen-depleting treatment, acidified drinking water.
Thus, administration of acidic drinking water does not appear to be an option for treating autoimmune diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jayaraman, Sundararajan& Jayaraman, Arathi. 2018. Long-Term Provision of Acidified Drinking Water Fails to Influence Autoimmune Diabetes and Encephalomyelitis. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1183461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jayaraman, Sundararajan& Jayaraman, Arathi. Long-Term Provision of Acidified Drinking Water Fails to Influence Autoimmune Diabetes and Encephalomyelitis. Journal of Diabetes Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1183461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jayaraman, Sundararajan& Jayaraman, Arathi. Long-Term Provision of Acidified Drinking Water Fails to Influence Autoimmune Diabetes and Encephalomyelitis. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1183461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر